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Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.

Abstract：

:Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in metastatic tumors. Periostin expression dramatically enhanced metastatic growth of colon cancer by both preventing stress-induced apoptosis in the cancer cells and augmenting endothelial cell survival to promote angiogenesis. At the molecular level, periostin activated the Akt/PKB signaling pathway through the alpha(v)beta(3) integrins to increase cellular survival. These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Bao S,Ouyang G,Bai X,Huang Z,Ma C,Liu M,Shao R,Anderson RM,Rich JN,Wang XF

doi

10.1016/s1535-6108(04)00081-9

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

329-39

issue

4

eissn

1535-6108

issn

1878-3686

pii

S1535610804000819

journal_volume

5

pub_type

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