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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

Abstract：

:BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity against lymphoma and small-cell lung cancer in preclinical studies. We here report that ABT-737 effectively kills acute myeloid leukemia blast, progenitor, and stem cells without affecting normal hematopoietic cells. ABT-737 induced the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. In cells with phosphorylated BCL-2 or increased MCL-1, ABT-737 was inactive. Inhibition of BCL-2 phosphorylation and reduction of MCL-1 expression restored sensitivity to ABT-737. These data suggest that ABT-737 could be a highly effective antileukemia agent when the mechanisms of resistance identified here are considered.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Konopleva M,Contractor R,Tsao T,Samudio I,Ruvolo PP,Kitada S,Deng X,Zhai D,Shi YX,Sneed T,Verhaegen M,Soengas M,Ruvolo VR,McQueen T,Schober WD,Watt JC,Jiffar T,Ling X,Marini FC,Harris D,Dietrich M,Estrov Z,McC

doi

10.1016/j.ccr.2006.10.006

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

375-88

issue

5

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(06)00313-8

journal_volume

10

pub_type

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