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Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.

Abstract：

:How loss-of-function of GATA3 contributes to the development of breast cancer is poorly understood. Here, we report that GATA3 nucleates a transcription repression program composed of G9A and MTA3-, but not MTA1- or MTA2-, constituted NuRD complex. Genome-wide analysis of the GATA3/G9A/NuRD(MTA3) targets identified a cohort of genes including ZEB2 that are critically involved in epithelial-to-mesenchymal transition and cell invasion. We demonstrate that the GATA3/G9A/NuRD(MTA3) complex inhibits the invasive potential of breast cancer cells in vitro and suppresses breast cancer metastasis in vivo. Strikingly, the expression of GATA3, G9A, and MTA3 is concurrently downregulated during breast cancer progression, leading to an elevated expression of ZEB2, which, in turn, represses the expression of G9A and MTA3 through the recruitment of G9A/NuRD(MTA1).

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Si W,Huang W,Zheng Y,Yang Y,Liu X,Shan L,Zhou X,Wang Y,Su D,Gao J,Yan R,Han X,Li W,He L,Shi L,Xuan C,Liang J,Sun L,Wang Y,Shang Y

doi

10.1016/j.ccell.2015.04.011

subject

Has Abstract

pub_date

2015-06-08 00:00:00

pages

822-36

issue

6

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(15)00144-0

journal_volume

27

pub_type

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