Abstract:
:Metastases arising from tumors have the proclivity to colonize specific organs, suggesting that they must rewire their biology to meet the demands of the organ colonized, thus altering their primary properties. Each metastatic site presents distinct metabolic challenges to a colonizing cancer cell, ranging from fuel and oxygen availability to oxidative stress. Here, we discuss the organ-specific metabolic adaptations that cancer cells must undergo, which provide the ability to overcome the unique barriers to colonization in foreign tissues and establish the metastatic tissue tropism phenotype.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Schild T,Low V,Blenis J,Gomes APdoi
10.1016/j.ccell.2018.02.001subject
Has Abstractpub_date
2018-03-12 00:00:00pages
347-354issue
3eissn
1535-6108issn
1878-3686pii
S1535-6108(18)30022-9journal_volume
33pub_type
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