Normal Somatic Mutations in Cancer Transformation.

Abstract:

:Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Wijewardhane N,Dressler L,Ciccarelli FD

doi

10.1016/j.ccell.2020.11.002

subject

Has Abstract

pub_date

2020-11-17 00:00:00

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(20)30594-8

pub_type

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