Abstract:
:Abnormal activation of the epidermal growth factor receptor (EGFR) and its homolog HER2 (Neu/ErbB2) has been associated with many human cancers, and monoclonal antibodies targeting EGFR and HER2 are effective anticancer therapies. Structural studies of these receptors and antibodies have revealed much about how they function. In this issue of Cancer Cell, Schmiedel et al. report structural and functional studies of the anti-EGFR monoclonal antibody Matuzumab. They show that Matuzumab binds and inhibits EGFR in a manner distinctive from that of other therapeutic anti-EGFR antibodies and suggest that combination therapies with Matuzumab and other antibodies may prove beneficial.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Leahy DJdoi
10.1016/j.ccr.2008.03.010subject
Has Abstractpub_date
2008-04-01 00:00:00pages
291-3issue
4eissn
1535-6108issn
1878-3686pii
S1535-6108(08)00093-7journal_volume
13pub_type
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