Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer.


:In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain developmental programs can be hijacked in cancer.


Cancer Cell


Cancer cell


Chheda MG,Gutmann DH




Has Abstract


2017-05-08 00:00:00














  • Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.

    abstract::Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e.g., T cell lymphoma (TCL). Here, Ca2+/calmodulin-dependent protein kinase II γ (CAMKIIγ) was shown to stabilize the c-Myc protein by direct...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Gu Y,Zhang J,Ma X,Kim BW,Wang H,Li J,Pan Y,Xu Y,Ding L,Yang L,Guo C,Wu X,Wu J,Wu K,Gan X,Li G,Li L,Forman SJ,Chan WC,Xu R,Huang W

    更新日期:2017-07-10 00:00:00

  • Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.

    abstract::Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling pathway. However, we show that the related cytokine IL-11 has a stronger correlation with elevated STAT3 activation in human gastrointestinal...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Putoczki TL,Thiem S,Loving A,Busuttil RA,Wilson NJ,Ziegler PK,Nguyen PM,Preaudet A,Farid R,Edwards KM,Boglev Y,Luwor RB,Jarnicki A,Horst D,Boussioutas A,Heath JK,Sieber OM,Pleines I,Kile BT,Nash A,Greten FR,McKe

    更新日期:2013-08-12 00:00:00

  • BRAF inhibitor unveils its potential against advanced melanoma.

    abstract::Unresponsiveness to therapy is a hallmark feature of advanced metastatic melanoma. However, the discovery of BRAF-activating mutations in approximately 50% of human melanomas has provided an attractive therapeutic target. Here, we discuss two recent publications focusing on the mutant BRAF kinase inhibitor PLX4032 tha...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Vultur A,Villanueva J,Herlyn M

    更新日期:2010-10-19 00:00:00

  • ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.

    abstract::MicroRNAs (miRNA) are mostly downregulated in cancer. However, the mechanism underlying this phenomenon and the precise consequence in tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation b...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Sun HL,Cui R,Zhou J,Teng KY,Hsiao YH,Nakanishi K,Fassan M,Luo Z,Shi G,Tili E,Kutay H,Lovat F,Vicentini C,Huang HL,Wang SW,Kim T,Zanesi N,Jeon YJ,Lee TJ,Guh JH,Hung MC,Ghoshal K,Teng CM,Peng Y,Croce CM

    更新日期:2016-11-14 00:00:00

  • H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia.

    abstract::Homeobox domain-containing transcription factors are important regulators of hematopoiesis. Here, we report that increased levels of nonclustered H2.0-like homeobox (HLX) lead to loss of functional hematopoietic stem cells and formation of aberrant progenitors with unlimited serial clonogenicity and blocked differenti...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Kawahara M,Pandolfi A,Bartholdy B,Barreyro L,Will B,Roth M,Okoye-Okafor UC,Todorova TI,Figueroa ME,Melnick A,Mitsiades CS,Steidl U

    更新日期:2012-08-14 00:00:00

  • GEMMs shine a light on resistance to androgen deprivation therapy for prostate cancer.

    abstract::Androgen deprivation therapy (ADT) for advanced prostate cancer inexorably leads to resistance, and clinically useful biomarkers are lacking. The value of genetically engineered mice for coclinical studies is clearly demonstrated in a recent publication that reveals XAF1, XIAP, and SRD5A1 as novel predictive biomarker...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Karantanos T,Thompson TC

    更新日期:2013-07-08 00:00:00

  • It's the peptide-MHC affinity, stupid.

    abstract::Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Kammertoens T,Blankenstein T

    更新日期:2013-04-15 00:00:00

  • The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation.

    abstract::Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblasto...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Pandey GK,Mitra S,Subhash S,Hertwig F,Kanduri M,Mishra K,Fransson S,Ganeshram A,Mondal T,Bandaru S,Ostensson M,Akyürek LM,Abrahamsson J,Pfeifer S,Larsson E,Shi L,Peng Z,Fischer M,Martinsson T,Hedborg F,Kogner P,

    更新日期:2014-11-10 00:00:00

  • RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.

    abstract::Although common cancer hallmarks are well established, lineage-restricted oncogenes remain less understood. Here, we report an inherent dependency of melanoma cells on the small GTPase RAB7, identified within a lysosomal gene cluster that distinguishes this malignancy from over 35 tumor types. Analyses in human cells,...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Alonso-Curbelo D,Riveiro-Falkenbach E,Pérez-Guijarro E,Cifdaloz M,Karras P,Osterloh L,Megías D,Cañón E,Calvo TG,Olmeda D,Gómez-López G,Graña O,Sánchez-Arévalo Lobo VJ,Pisano DG,Wang HW,Ortiz-Romero P,Tormo D,Hoek K,Ro

    更新日期:2014-07-14 00:00:00

  • Metastatic colon cancer cells negotiate the intravasation Notch.

    abstract::In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion,...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Christofori G

    更新日期:2011-01-18 00:00:00

  • c-Raf in KRas Mutant Cancers: A Moving Target.

    abstract::Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid's group validate c-Raf as a prime target for these cancers. c-Raf ablation caused regression of advanced KRasG12V/Trp53 tumors, without obvious systemic toxicity and without affec...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: McCormick F

    更新日期:2018-02-12 00:00:00

  • Species- and cell type-specific requirements for cellular transformation.

    abstract::Recent evidence suggests that human cells require more genetic changes for neoplastic transformation than do their murine counterparts. However, a precise enumeration of these differences has never been undertaken. We have determined that perturbation of two signaling pathways-involving p53 and Raf-suffices for the tu...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Rangarajan A,Hong SJ,Gifford A,Weinberg RA

    更新日期:2004-08-01 00:00:00

  • PI3K regulatory subunits lose control in cancer.

    abstract::The PI3K signaling axis is frequently activated in cancer resulting from inactivation of its negative regulator PTEN or activating mutations of the p110alpha catalytic subunit of PI3K. In this issue of Cancer Cell, Jaiswal et al. report that mutations in the p85alpha regulatory subunit of PI3K can also activate this p...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Berenjeno IM,Vanhaesebroeck B

    更新日期:2009-12-08 00:00:00

  • HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice.

    abstract::Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs regulate hematopoietic stem cell (HSC) function and contribute to leukemogenesis remains elusive. We found that HOTTIP is aberrantly activated i...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Luo H,Zhu G,Xu J,Lai Q,Yan B,Guo Y,Fung TK,Zeisig BB,Cui Y,Zha J,Cogle C,Wang F,Xu B,Yang FC,Li W,So CWE,Qiu Y,Xu M,Huang S

    更新日期:2019-12-09 00:00:00

  • CHAF1B Overexpression: A Brake for the Differentiation of Leukemia Cells.

    abstract::In this issue of Cancer Cell, Volk et al. report that overexpression of CHAF1B displaces myeloid transcription factors from chromatin, and deletion of CHAF1B promotes differentiation of leukemia cells and suppresses leukemogenesis in a murine model, revealing a causal role of and an unexpected mechanism for CHAF1B ove...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Li Q,Zhang X,Zhang Z

    更新日期:2018-11-12 00:00:00

  • Immunometabolic Interplay in the Tumor Microenvironment.

    abstract::Immune cells' metabolism influences their differentiation and function. Given that a complex interplay of environmental factors within the tumor microenvironment (TME) can have a profound impact on the metabolic activities of immune, stromal, and tumor cell types, there is emerging interest to advance understanding of...

    journal_title:Cancer cell

    pub_type: 杂志文章,评审


    authors: Kaymak I,Williams KS,Cantor JR,Jones RG

    更新日期:2021-01-11 00:00:00

  • Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.

    abstract::A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, we developed mice that lack beta-catenin in their hematopoietic cells. Here we show that beta-catenin-deficient mic...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Zhao C,Blum J,Chen A,Kwon HY,Jung SH,Cook JM,Lagoo A,Reya T

    更新日期:2007-12-01 00:00:00

  • The potential of new tumor endothelium-specific markers for the development of antivascular therapy.

    abstract::Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a ...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Li JL,Harris AL

    更新日期:2007-06-01 00:00:00

  • Inactivation of E2F3 results in centrosome amplification.

    abstract::The E2F family of transcription factors is critical for the control of cell cycle progression. We now show that the specific inactivation of E2F3 in mouse embryo fibroblasts (MEFs) results in a disruption of the centrosome duplication cycle. Loss of E2F3, but not E2F1, E2F2, E2F4, or E2F5 results in unregulated cyclin...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Saavedra HI,Maiti B,Timmers C,Altura R,Tokuyama Y,Fukasawa K,Leone G

    更新日期:2003-04-01 00:00:00

  • Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.

    abstract::Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation of NE prostate tumors in the TRAMP mouse model was suppressed in mice lacking the ubiquitin ligase Siah2, which regulates HIF-1alpha availability. Cooperation be...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Qi J,Nakayama K,Cardiff RD,Borowsky AD,Kaul K,Williams R,Krajewski S,Mercola D,Carpenter PM,Bowtell D,Ronai ZA

    更新日期:2010-07-13 00:00:00

  • Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia.

    abstract::Activating mutations in the FLT3 receptor tyrosine kinase occur in 30% of patients with acute myeloid leukemia. Small molecule FLT3 kinase inhibitors show selective antitumor activity in preclinical models. Clinical studies are underway. ...

    journal_title:Cancer cell

    pub_type: 杂志文章,评审


    authors: Sawyers CL

    更新日期:2002-06-01 00:00:00

  • PIKK-ing a new partner: a new role for PKB in the DNA damage response.

    abstract::The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-dama...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Lees-Miller SP

    更新日期:2008-05-01 00:00:00

  • Of Snail, mice, and women.

    abstract::Mechanisms for breast cancer recurrence and metastases are poorly understood. New evidence from a transgenic mouse mammary tumor model suggests that the transcriptional repressor, Snail, may play a role in recurrence by downregulating E-cadherin and inducing an epithelial-to-mesenchymal transition. Preliminary informa...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Davidson NE,Sukumar S

    更新日期:2005-09-01 00:00:00

  • Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs.

    abstract::Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that anti-angiogenic drugs, such as bevacizumab, transiently normalize abnormal tumor vasculature and contribute to improved delivery of subsequent chemotherapy. To investigate this concept, ...

    journal_title:Cancer cell

    pub_type: 临床试验,杂志文章


    authors: Van der Veldt AA,Lubberink M,Bahce I,Walraven M,de Boer MP,Greuter HN,Hendrikse NH,Eriksson J,Windhorst AD,Postmus PE,Verheul HM,Serné EH,Lammertsma AA,Smit EF

    更新日期:2012-01-17 00:00:00

  • CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.

    abstract::During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor versus antitumor immunity in the breast remains poorly understood. Utilizing the MMTV-PyMT model of mammary carcinogenesis, we...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: DeNardo DG,Barreto JB,Andreu P,Vasquez L,Tawfik D,Kolhatkar N,Coussens LM

    更新日期:2009-08-04 00:00:00

  • Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.

    abstract::Hepatocyte I kappaB kinase beta (IKK beta) inhibits hepatocarcinogenesis by suppressing accumulation of reactive oxygen species (ROS) and liver damage, whereas JNK1 activation promotes ROS accumulation, liver damage, and carcinogenesis. We examined whether hepatocyte p38 alpha, found to inhibit liver carcinogenesis, a...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Sakurai T,He G,Matsuzawa A,Yu GY,Maeda S,Hardiman G,Karin M

    更新日期:2008-08-12 00:00:00

  • Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.

    abstract::Chronic exposure to tobacco smoke, which contains over 60 tumor-initiating carcinogens, is the major risk factor for development of lung cancer, accounting for a large portion of cancer-related deaths worldwide. It is well established that tobacco smoke is a tumor initiator, but we asked whether it also acts as a tumo...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Takahashi H,Ogata H,Nishigaki R,Broide DH,Karin M

    更新日期:2010-01-19 00:00:00

  • Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

    abstract::BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity against lymphoma and small-cell lung cancer in preclinical studies. We here report that ABT-737 effectively kills acute myeloid leukemia blast, progenitor, and...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Konopleva M,Contractor R,Tsao T,Samudio I,Ruvolo PP,Kitada S,Deng X,Zhai D,Shi YX,Sneed T,Verhaegen M,Soengas M,Ruvolo VR,McQueen T,Schober WD,Watt JC,Jiffar T,Ling X,Marini FC,Harris D,Dietrich M,Estrov Z,McC

    更新日期:2006-11-01 00:00:00

  • Tissue culture as a hostile environment: identifying conditions for breast cancer progression studies.

    abstract::The cell culture environment (substrate, atmosphere, and medium) can have a significant influence on the characteristics of cells that propagate from clinical samples. In this issue of Cancer Cell, Ince and colleagues report improved conditions for the culture of primary human breast epithelial cells. They demonstrate...

    journal_title:Cancer cell

    pub_type: 杂志文章,评审


    authors: Shay JW,Wright WE

    更新日期:2007-08-01 00:00:00

  • A Systematic Framework to Rapidly Obtain Data on Patients with Cancer and COVID-19: CCC19 Governance, Protocol, and Quality Assurance.

    abstract::When the COVID-19 pandemic began, formal frameworks to collect data about affected patients were lacking. The COVID-19 and Cancer Consortium (CCC19) was formed to collect granular data on patients with cancer and COVID-19 at scale and as rapidly as possible. CCC19 has grown from five initial institutions to 125 instit...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: COVID-19 and Cancer Consortium. Electronic address:,COVID-19 and Cancer Consortium.

    更新日期:2020-12-14 00:00:00