14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.

abstract：:Mutations in VHL, RET, NF1, SDHB, SDHC, and SDHD can give rise to pheochromocytoma/paraganglioma. These different genetic lesions may all act by decreasing the activity of a 2-oxoglutarate-dependent oxygenase, SM-20/EglN3/PHD3, resulting in reduced apoptosis of neural crest cells during development. ...

journal_title：Cancer cell

authors： Maxwell PH

更新日期：2005-08-01 00:00:00

abstract：:Solid tumors require new blood vessels for growth and metastasis, yet the biology of tumor-specific endothelial cells is poorly understood. We have isolated tumor endothelial cells from mice that spontaneously develop prostate tumors. Clonal populations of tumor endothelial cells expressed hematopoietic and mesenchyma...

journal_title：Cancer cell

authors： Dudley AC,Khan ZA,Shih SC,Kang SY,Zwaans BM,Bischoff J,Klagsbrun M

更新日期：2008-09-09 00:00:00

abstract：:There are 17 known ubiquitin-like proteins (UBLs) from nine phylogenetically distinct classes (NEDD8, SUMO, ISG15, FUB1, FAT10, Atg8, Atg12, Urm1, and UFM1) that have been identified to conjugate to substrates in a manner analogous to ubiquitin. NEDD8 is one of the most studied UBLs and shares the highest amino acid s...

journal_title：Cancer cell

authors： Watson IR,Irwin MS,Ohh M

更新日期：2011-02-15 00:00:00

abstract：:Activating mutations in BRAF are the most common genetic alterations in melanoma. Inhibition of BRAF by small molecules leads to cell-cycle arrest and apoptosis. We show here that BRAF inhibition also induces an oxidative phosphorylation gene program, mitochondrial biogenesis, and the increased expression of the mitoc...

journal_title：Cancer cell

authors： Haq R,Shoag J,Andreu-Perez P,Yokoyama S,Edelman H,Rowe GC,Frederick DT,Hurley AD,Nellore A,Kung AL,Wargo JA,Song JS,Fisher DE,Arany Z,Widlund HR

更新日期：2013-03-18 00:00:00

abstract：:Ampullary carcinomas represent a group of heterogeneous tumors that can be histologically divided into two subtypes with distinct pathogenic and clinical characteristics. Yachida et al. (2016) and Gingras et al. (2016) now report the genomic landscape of ampullary carcinoma, providing insights into molecular drivers w...

journal_title：Cancer cell

authors： Tan J,Tan P,Teh BT

更新日期：2016-02-08 00:00:00

abstract：:The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggabl...

journal_title：Cancer cell

authors： Bunda S,Zadeh G,Aldape KD

更新日期：2017-12-11 00:00:00

abstract：:Antiangiogenic tumor therapy has failed in the adjuvant setting. Here we show that inhibition of the Tie2 ligand angiopoietin-2 (Ang2) effectively blocks metastatic growth in preclinical mouse models of postsurgical adjuvant therapy. Ang2 antibody treatment combines well with low-dose metronomic chemotherapy (LDMC) in...

journal_title：Cancer cell

authors： Srivastava K,Hu J,Korn C,Savant S,Teichert M,Kapel SS,Jugold M,Besemfelder E,Thomas M,Pasparakis M,Augustin HG

更新日期：2014-12-08 00:00:00

abstract：:Ependymoma is the third most common pediatric tumor with posterior fossa group A (PFA) being its most aggressive subtype. Ependymomas are generally refractory to chemotherapies and thus lack any effective treatment. Here, we report that elevated expression of CXorf67 (chromosome X open reading frame 67), which frequen...

journal_title：Cancer cell

authors： Han J,Yu M,Bai Y,Yu J,Jin F,Li C,Zeng R,Peng J,Li A,Song X,Li H,Wu D,Li L

更新日期：2020-12-14 00:00:00

abstract：:Metastasis and therapy resistance are cardinal features of pancreatic ductal adenocarcinoma, a commonly lethal malignancy. In this issue of Cancer Cell, Steele et al. show that CXCR2 expression and neutrophils are required for metastasis. In mice treated with advanced disease, inhibiting both CXCR2 and PD1 cooperative...

journal_title：Cancer cell

authors： Stromnes IM,Greenberg PD

更新日期：2016-06-13 00:00:00

abstract：:We demonstrate that concurrent administration of poly(ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly tolerated. Concurrent treatment with PARP and WEE1 inhibitors induces replication stress, DNA damage, and abrogates the G2 DNA damage checkpoint in both normal and ...

journal_title：Cancer cell

authors： Fang Y,McGrail DJ,Sun C,Labrie M,Chen X,Zhang D,Ju Z,Vellano CP,Lu Y,Li Y,Jeong KJ,Ding Z,Liang J,Wang SW,Dai H,Lee S,Sahni N,Mercado-Uribe I,Kim TB,Chen K,Lin SY,Peng G,Westin SN,Liu J,O'Connor MJ,Yap T

更新日期：2019-06-10 00:00:00

abstract：:The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs). Silencing ALKBH5 suppresses the proliferation ...

journal_title：Cancer cell

authors： Zhang S,Zhao BS,Zhou A,Lin K,Zheng S,Lu Z,Chen Y,Sulman EP,Xie K,Bögler O,Majumder S,He C,Huang S

更新日期：2017-04-10 00:00:00

abstract：:In this issue of Cancer Cell, Kudo et al. identify a novel tumor suppressor role for PKCλ/ι in hepatocellular carcinoma. Loss of PKCλ/ι in obesity-driven liver cancer results in cellular metabolic reprogramming that induces two reciprocally sustainable processes, oxidative phosphorylation and autophagy, which promote ...

journal_title：Cancer cell

authors： Ramadori P,Li X,Heikenwalder M

更新日期：2020-08-10 00:00:00

abstract：:A fundamental property of cancer cells is the preferential utilization of glycolysis over aerobic respiration to produce ATP. Renewed interest in understanding the mechanism underlying this metabolic shift in energy production is broadening our understanding of the relationship between cancer and cellular metabolism. ...

journal_title：Cancer cell

authors： Assaily W,Benchimol S

更新日期：2006-07-01 00:00:00

abstract：:Cancer therapeutics are primarily thought to work by inducing apoptosis in tumor cells. However, various tumor suppressors and oncogenes have been shown to regulate senescence in normal cells, and senescence bypass appears to be an important step in the development of cancer. Cellular senescence limits the replicative...

journal_title：Cancer cell

authors： Dimri GP

更新日期：2005-06-01 00:00:00

abstract：:Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations in 50% (22 of 44) of resistant BCCs and show that these mutations maintain Hedgehog signaling in the presence of SMO inhibitors. Alterations include four ligand ...

journal_title：Cancer cell

authors： Atwood SX,Sarin KY,Whitson RJ,Li JR,Kim G,Rezaee M,Ally MS,Kim J,Yao C,Chang AL,Oro AE,Tang JY

更新日期：2015-03-09 00:00:00

abstract：:Wnt/β-catenin signaling is essential for stem cell regulation and tumorigenesis, but its molecular mechanisms are not fully understood. Here, we report that FoxM1 is a downstream component of Wnt signaling and is critical for β-catenin transcriptional function in tumor cells. Wnt3a increases the level and nuclear tran...

journal_title：Cancer cell

authors： Zhang N,Wei P,Gong A,Chiu WT,Lee HT,Colman H,Huang H,Xue J,Liu M,Wang Y,Sawaya R,Xie K,Yung WK,Medema RH,He X,Huang S

更新日期：2011-10-18 00:00:00

abstract：:In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. The results suggest that ...

journal_title：Cancer cell

authors： Mederacke I,Schwabe RF

更新日期：2014-12-08 00:00:00

abstract：:The BCL6 gene is a key factor necessary for formation of germinal centers and is implicated in pathogenesis of diffuse large B cell lymphoma (DLBCL). In this issue of Cancer Cell, Saito and colleagues explore regulation of BCL6 gene expression by CD40-NF-kappaB signaling pathway and show that the IRF4 transcriptional ...

journal_title：Cancer cell

authors： Lossos IS

更新日期：2007-09-01 00:00:00

abstract：:BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity against lymphoma and small-cell lung cancer in preclinical studies. We here report that ABT-737 effectively kills acute myeloid leukemia blast, progenitor, and...

journal_title：Cancer cell

authors： Konopleva M,Contractor R,Tsao T,Samudio I,Ruvolo PP,Kitada S,Deng X,Zhai D,Shi YX,Sneed T,Verhaegen M,Soengas M,Ruvolo VR,McQueen T,Schober WD,Watt JC,Jiffar T,Ling X,Marini FC,Harris D,Dietrich M,Estrov Z,McC

更新日期：2006-11-01 00:00:00

abstract：:The increased motility and invasiveness of tumor cells are reminiscent of epithelial-mesenchymal transition (EMT), which occurs during embryonic development, wound healing, and metastasis. In this study, we found that Snail is stabilized by the inflammatory cytokine TNFalpha through the activation of the NF-kappaB pat...

journal_title：Cancer cell

authors： Wu Y,Deng J,Rychahou PG,Qiu S,Evers BM,Zhou BP

更新日期：2009-05-05 00:00:00

abstract：:Whether metastasis-specific genetic alterations exist remains controversial. The study by Yates et al. in this issue of Cancer Cell provides evidence that metastases emerge late during primary breast cancer progression and that additional driver mutations are often acquired, posing both challenges and opportunities fo...

journal_title：Cancer cell

authors： Zhao X,Powers S

更新日期：2017-08-14 00:00:00

abstract：:The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become addicted to targetable signaling pathways. A comprehensive (phospho)proteomic ...

journal_title：Cancer cell

authors： Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C

更新日期：2017-04-10 00:00:00

abstract：:Identifying contexts in which cancer cells become addicted to specific nutrients is critical for developing targeted metabolic therapies. In this issue of Cancer Cell, Momcilovic et al. report that suppressed glycolysis following mTOR inhibition is countered by adaptive glutamine catabolism in lung squamous cell carci...

journal_title：Cancer cell

authors： Lukey MJ,Katt WP,Cerione RA

更新日期：2018-05-14 00:00:00

abstract：:Malignant astrocytomas are infiltrative and incurable brain tumors. Despite profound therapeutic implications, the identity of the cell (or cells) of origin has not been rigorously determined. We previously reported mouse models based on conditional inactivation of the human astrocytoma-relevant tumor suppressors p53,...

journal_title：Cancer cell

authors： Alcantara Llaguno S,Chen J,Kwon CH,Jackson EL,Li Y,Burns DK,Alvarez-Buylla A,Parada LF

更新日期：2009-01-06 00:00:00

abstract：:In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles, and have identified gene and phosphoprotein signatures associated with Lk...

journal_title：Cancer cell

authors： Carretero J,Shimamura T,Rikova K,Jackson AL,Wilkerson MD,Borgman CL,Buttarazzi MS,Sanofsky BA,McNamara KL,Brandstetter KA,Walton ZE,Gu TL,Silva JC,Crosby K,Shapiro GI,Maira SM,Ji H,Castrillon DH,Kim CF,García-Echeve

更新日期：2010-06-15 00:00:00

abstract：:The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions. EZH2 represses proliferation checkpoint genes and helps establish bivalent ch...

journal_title：Cancer cell

authors： Béguelin W,Popovic R,Teater M,Jiang Y,Bunting KL,Rosen M,Shen H,Yang SN,Wang L,Ezponda T,Martinez-Garcia E,Zhang H,Zheng Y,Verma SK,McCabe MT,Ott HM,Van Aller GS,Kruger RG,Liu Y,McHugh CF,Scott DW,Chung YR,Kel

更新日期：2013-05-13 00:00:00

abstract：:Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy...

journal_title：Cancer cell

authors： Kammertoens T,Blankenstein T

更新日期：2013-04-15 00:00:00

abstract：:Chromosome rearrangements in B lymphocytes can be initiated by AID-associated double strand breaks (DSBs), with others arising by unclear mechanisms. A recent study by Barlow and colleagues in Cell reports on genomic regions, termed early replicating fragile sites, that may explain many AID-independent DSBs and create...

journal_title：Cancer cell

authors： Glover TW,Wilson TE

更新日期：2013-02-11 00:00:00

abstract：:We identified dynein light chain 1 (DLC1) as a physiologic substrate of p21-activated kinase 1 (Pak1). Pak1-DLC1 interaction plays an essential role in cell survival, which depends on Pak1's phosphorylation of DLC1 on Ser88. Pak1 associates with the complex of DLC1 and BimL, a proapoptotic BH3-only protein, and phosph...

journal_title：Cancer cell

authors： Vadlamudi RK,Bagheri-Yarmand R,Yang Z,Balasenthil S,Nguyen D,Sahin AA,den Hollander P,Kumar R

更新日期：2004-06-01 00:00:00

abstract：:Mutations in the EGFR kinase are a cause of non-small-cell lung cancer. To understand their mechanism of activation and effects on drug binding, we studied the kinetics of the L858R and G719S mutants and determined their crystal structures with inhibitors including gefitinib, AEE788, and a staurosporine. We find that ...

journal_title：Cancer cell

authors： Yun CH,Boggon TJ,Li Y,Woo MS,Greulich H,Meyerson M,Eck MJ

更新日期：2007-03-01 00:00:00