Abstract:
:In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. The results suggest that supplementation of NAD(+) may be a prophylactic or therapeutic approach in HCC.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Mederacke I,Schwabe RFdoi
10.1016/j.ccell.2014.11.011subject
Has Abstractpub_date
2014-12-08 00:00:00pages
777-778issue
6eissn
1535-6108issn
1878-3686pii
S1535-6108(14)00462-0journal_volume
26pub_type
评论,杂志文章相关文献
CANCER CELL文献大全abstract::Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21(CIP1) checkpoint and cellular senescence at early stages of c...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.01.021
更新日期:2012-04-17 00:00:00
abstract::MicroRNAs (miRNA) are mostly downregulated in cancer. However, the mechanism underlying this phenomenon and the precise consequence in tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation b...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.10.001
更新日期:2016-11-14 00:00:00
abstract::The nervous system is emerging as a regulator of malignancy. In this issue of Cancer Cell, Hayakawa et al. demonstrate a feedforward signaling loop in which tumor-derived nerve growth factor promotes enteric tumor innervation, and recruited nerves drive cancer growth through acetylcholine-regulated Wnt signaling and s...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.12.008
更新日期:2017-01-09 00:00:00
abstract::Identifying contexts in which cancer cells become addicted to specific nutrients is critical for developing targeted metabolic therapies. In this issue of Cancer Cell, Momcilovic et al. report that suppressed glycolysis following mTOR inhibition is countered by adaptive glutamine catabolism in lung squamous cell carci...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2018.04.009
更新日期:2018-05-14 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) play a major role in cancer. MDSC expansion is closely associated with tumor progression, but molecular mechanisms of this expansion remain poorly understood. In this issue of Cancer Cell, Strauss and colleagues describe the roles of the nuclear receptor ROR1C in the regulation...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2015.07.007
更新日期:2015-08-10 00:00:00
abstract::Monosomy 7 and interstitial deletion of 7q (-7/7q-) are well-recognized nonrandom chromosomal abnormalities frequently found among patients with myelodysplastic syndromes (MDSs) and myeloid leukemias. We previously identified candidate myeloid tumor suppressor genes (SAMD9, SAMD9-like = SAMD9L, and Miki) in the 7q21.3...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.08.011
更新日期:2013-09-09 00:00:00
abstract::Constitutive activation of NF-κB signaling can promote oncogenesis, providing a rationale for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes & Development provide evidence that, in contexts where prosurvival signals derive from other oncogenes, NF-κB activity instead enhances sens...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2011.10.026
更新日期:2011-11-15 00:00:00
abstract::The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions. EZH2 represses proliferation checkpoint genes and helps establish bivalent ch...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.04.011
更新日期:2013-05-13 00:00:00
abstract::We show that imatinib, nilotinib, and dasatinib possess weak off-target activity against RAF and, therefore, drive paradoxical activation of BRAF and CRAF in a RAS-dependent manner. Critically, because RAS is activated by BCR-ABL, in drug-resistant chronic myeloid leukemia (CML) cells, RAS activity persists in the pre...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.11.004
更新日期:2011-12-13 00:00:00
abstract::Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes. In mouse skin tumorigenesis, Par3 deficiency results in reduced papilloma formation and growth. Par3 mediates its tumor-promoting activity through regulation of grow...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.08.004
更新日期:2012-09-11 00:00:00
abstract::Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblasto...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.09.014
更新日期:2014-11-10 00:00:00
abstract::In this study, we show that the formation of polyploidy following sustained mitotic checkpoint activation appears to be preceded by the ubiquitin-dependent proteolysis of hBubR1. In addition, the level of hBubR1 is significantly reduced not only in polyploid cells created by sustained mitotic spindle damage, but also ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(03)00302-7
更新日期:2003-12-01 00:00:00
abstract::The proapoptotic death receptor DR5 has been studied extensively in cancer cells, but its action in the tumor microenvironment is not well defined. Here, we uncover a role for DR5 signaling in tumor endothelial cells (ECs). We detected DR5 expression in ECs within tumors but not normal tissues. Treatment of tumor-bear...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.05.014
更新日期:2012-07-10 00:00:00
abstract::Genital human papillomavirus (HPV) infection is causally linked to the development of cervical cancer, a leading cause of cancer-related mortality in women worldwide. Recent studies demonstrate the effectiveness of virus-like particle-based vaccines to induce neutralizing antibodies against HPV and prevent cervical in...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(02)00239-8
更新日期:2003-01-01 00:00:00
abstract::Receptor tyrosine kinase (RTK) recycling is of critical importance for RTK signaling and cancer, yet the process is poorly understood. In this issue, Ye et al. identify GOLM1 as a cargo adaptor that drives hepatocellular carcinoma metastasis by promoting EGFR recycling and provide insights into how this process is reg...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.08.014
更新日期:2016-09-12 00:00:00
abstract::The hedgehog (Hh) signaling pathway plays many roles in invertebrate and vertebrate development. For example, specific inhibition of sonic Hh expression is critical during early stages of pancreas organogenesis, but an active Hh pathway appears to be required for maintenance of adult endocrine functions. Mutational in...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(03)00246-0
更新日期:2003-10-01 00:00:00
abstract::Ampullary carcinomas represent a group of heterogeneous tumors that can be histologically divided into two subtypes with distinct pathogenic and clinical characteristics. Yachida et al. (2016) and Gingras et al. (2016) now report the genomic landscape of ampullary carcinoma, providing insights into molecular drivers w...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.01.011
更新日期:2016-02-08 00:00:00
abstract::p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs). Although p62 was proposed to participate in the formation of benign adenomas in autophagy-deficient livers, its role in HCC initiation was not explored. Here we...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.04.006
更新日期:2016-06-13 00:00:00
abstract::Cancer therapeutics are primarily thought to work by inducing apoptosis in tumor cells. However, various tumor suppressors and oncogenes have been shown to regulate senescence in normal cells, and senescence bypass appears to be an important step in the development of cancer. Cellular senescence limits the replicative...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccr.2005.05.025
更新日期:2005-06-01 00:00:00
abstract::It is widely accepted that metastasis is a late event in cancer progression. Here, however, we show that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women. Wild-type mice transplanted with single premalignant HER-2...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2007.12.003
更新日期:2008-01-01 00:00:00
abstract::HIF-2alpha promotes von Hippel-Lindau (VHL)-deficient renal clear cell carcinoma (RCC) tumorigenesis, while HIF-1alpha inhibits RCC growth. As HIF-1alpha antagonizes c-Myc function, we hypothesized that HIF-2alpha might enhance c-Myc activity. We demonstrate here that HIF-2alpha promotes cell-cycle progression in hypo...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2007.02.006
更新日期:2007-04-01 00:00:00
abstract::Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2018.03.002
更新日期:2018-06-11 00:00:00
abstract::The erythroleukemia developed by spi-1/PU.1 transgenic mice is a multistage process characterized by an early arrest of the proerythroblast differentiation followed later on by malignant transformation. Herein, we report the presence of acquired mutations in the SCF receptor gene (Kit) in 86% of tumors isolated during...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.11.009
更新日期:2005-12-01 00:00:00
abstract::Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.10.010
更新日期:2016-12-12 00:00:00
abstract::MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single nucleotide polymorphism (SNP) in the human MDM2 promoter increases the affinity of Sp1 resulting in elevated MDM2 levels. We generated mice carrying either the MDM2(SNP309T) or the MDM2(SNP309G) allele to address the imp...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2010.07.010
更新日期:2010-09-14 00:00:00
abstract::Abnormal activation of the epidermal growth factor receptor (EGFR) and its homolog HER2 (Neu/ErbB2) has been associated with many human cancers, and monoclonal antibodies targeting EGFR and HER2 are effective anticancer therapies. Structural studies of these receptors and antibodies have revealed much about how they f...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2008.03.010
更新日期:2008-04-01 00:00:00
abstract::Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups of pHGGs. Here, we provide further insight about the dominant-negative effect of K27M mutant H3.3, leading to a global reduction of the r...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.10.006
更新日期:2013-11-11 00:00:00
abstract::We report that mouse LSL-KrasG12D;Trp53fl/fl (KP)-mediated lung adenocarcinoma (LADC) tumorigenesis can proceed through both PKCι-dependent and PKCι-independent pathways. The predominant pathway involves PKCι-dependent transformation of bronchoalveolar stem cells (BASCs). However, KP mice harboring conditional knock o...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2019.07.002
更新日期:2019-08-12 00:00:00
abstract::Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms underlying NASH and NASH-induced HCC are largely unknown. We developed a mouse model recapitulating key features of human metabolic syndrome, NASH, ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.09.003
更新日期:2014-10-13 00:00:00
abstract::ERK pathway activation in cells expressing wild-type BRAF is a well-reported, clinically-relevant adverse effect of the otherwise impressive response of BRAF(V600E)-mutated melanomas to RAF inhibitors. In this issue of Cancer Cell, Holderfield and colleagues show that RAF autoinhibition underpins this paradox, further...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2013.04.021
更新日期:2013-05-13 00:00:00