Abstract:
:Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Haemmerle M,Stone RL,Menter DG,Afshar-Kharghan V,Sood AKdoi
10.1016/j.ccell.2018.03.002subject
Has Abstractpub_date
2018-06-11 00:00:00pages
965-983issue
6eissn
1535-6108issn
1878-3686pii
S1535-6108(18)30070-9journal_volume
33pub_type
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