Abstract:
:Immune checkpoint blockade therapies fail to induce responses in the majority of cancer patients, so how to increase the objective response rate becomes an urgent challenge. Here, we demonstrate that sufficient T cell infiltration in tumor tissues is a prerequisite for response to PD-L1 blockade. Targeting tumors with tumor necrosis factor superfamily member LIGHT activates lymphotoxin β-receptor signaling, leading to the production of chemokines that recruit massive numbers of T cells. Furthermore, targeting non-T cell-inflamed tumor tissues by antibody-guided LIGHT creates a T cell-inflamed microenvironment and overcomes tumor resistance to checkpoint blockade. Our data indicate that targeting LIGHT might be a potent strategy to increase the responses to checkpoint blockades and other immunotherapies in non-T cell-inflamed tumors.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Tang H,Wang Y,Chlewicki LK,Zhang Y,Guo J,Liang W,Wang J,Wang X,Fu YXdoi
10.1016/j.ccell.2016.02.004subject
Has Abstractpub_date
2016-03-14 00:00:00pages
285-296issue
3eissn
1535-6108issn
1878-3686pii
S1535-6108(16)30038-1journal_volume
29pub_type
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