Abstract:
:The life history of cancer cells encompasses a series of genetic missteps in which normal cells are progressively transformed into tumor cells that invade surrounding tissues and become malignant. Most prominent among the regulators disrupted in cancer cells are two tumor suppressors, the retinoblastoma protein (RB) and the p53 transcription factor. Here, we discuss interconnecting signaling pathways controlled by RB and p53, attempting to explain their potentially universal involvement in the etiology of cancer. Pinpointing the various ways by which the functions of RB and p53 are subverted in individual tumors should provide a rational basis for developing more refined tumor-specific therapies.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Sherr CJ,McCormick Fdoi
10.1016/s1535-6108(02)00102-2keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
103-12issue
2eissn
1535-6108issn
1878-3686pii
S1535610802001022journal_volume
2pub_type
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