Abstract:
:Tight control of the tyrosine kinase activity of c-Src is critical for regulating its oncogenic potential. In a recent issue of Molecular Cell, Oneyama et al. (2008a) report that the membrane-bound adaptor protein Cbp (also known as PAG) can suppress c-Src-mediated cell transformation and tumorigenesis by binding and sequestering c-Src within lipid rafts. Cbp is also a raft-associated binding partner for Csk, a negative regulator of c-Src. However, the authors show that Cbp-mediated Src suppression is Csk independent. These findings suggest that Cbp is a tumor suppressor whose expression is downregulated during Src-driven cancer progression.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Resh MDdoi
10.1016/j.ccr.2008.05.011subject
Has Abstractpub_date
2008-06-01 00:00:00pages
469-71issue
6eissn
1535-6108issn
1878-3686pii
S1535-6108(08)00161-Xjournal_volume
13pub_type
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