当前位置： SCI文献检索 > CANCER CELL期刊下所有文献 > MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.

MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.

Abstract：

:The hypoxic tumor microenvironment serves as a niche for maintaining the glioma-initiating cells (GICs) that are critical for glioblastoma (GBM) occurrence and recurrence. Here, we report that hypoxia-induced miR-215 is vital for reprograming GICs to fit the hypoxic microenvironment via suppressing the expression of an epigenetic regulator KDM1B and modulating activities of multiple pathways. Interestingly, biogenesis of miR-215 and several miRNAs is accelerated post-transcriptionally by hypoxia-inducible factors (HIFs) through HIF-Drosha interaction. Moreover, miR-215 expression correlates inversely with KDM1B while correlating positively with HIF1α and GBM progression in patients. These findings reveal a direct role of HIF in regulating miRNA biogenesis and consequently activating the miR-215-KDM1B-mediated signaling required for GIC adaptation to hypoxia.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Hu J,Sun T,Wang H,Chen Z,Wang S,Yuan L,Liu T,Li HR,Wang P,Feng Y,Wang Q,McLendon RE,Friedman AH,Keir ST,Bigner DD,Rathmell J,Fu XD,Li QJ,Wang H,Wang XF

doi

10.1016/j.ccell.2015.12.005

subject

Has Abstract

pub_date

2016-01-11 00:00:00

pages

49-60

issue

1

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(15)00469-9

journal_volume

29

pub_type

杂志文章

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