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A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.

Abstract：

:MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single nucleotide polymorphism (SNP) in the human MDM2 promoter increases the affinity of Sp1 resulting in elevated MDM2 levels. We generated mice carrying either the MDM2(SNP309T) or the MDM2(SNP309G) allele to address the impact of MDM2(SNP309G) on tumorigenesis. Mdm2(SNP309G/G) cells exhibit elevated Mdm2 levels, reduced p53 levels, and decreased apoptosis. Importantly, some Mdm2(SNP309G/G) mice succumbed to tumors before 1 year of age, suggesting that this allele increases tumor risk. Additionally, the Mdm2(SNP309G) allele potentiates the tumor phenotype and alters tumor spectrum in mice inheriting a p53 hot-spot mutation. These data provide causal evidence for increased cancer risk in carriers of the Mdm2(SNP309G) allele.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Post SM,Quintás-Cardama A,Pant V,Iwakuma T,Hamir A,Jackson JG,Maccio DR,Bond GL,Johnson DG,Levine AJ,Lozano G

doi

10.1016/j.ccr.2010.07.010

subject

Has Abstract

pub_date

2010-09-14 00:00:00

pages

220-30

issue

3

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(10)00303-X

journal_volume

18

pub_type

评论,杂志文章

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