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Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

Abstract：

:The receptor tyrosine kinase HER2 enhances tumor metastasis; however, its role in homing to metastatic organs is poorly understood. The chemokine receptor CXCR4 has recently been shown to mediate the movement of malignant cancer cells to specific organs. Here, we show that HER2 enhances the expression of CXCR4, which is required for HER2-mediated invasion in vitro and lung metastasis in vivo. HER2 also inhibits ligand-induced CXCR4 degradation. Finally, a significant correlation between HER2 and CXCR4 expression was observed in human breast tumor tissues, and CXCR4 expression correlated with a poor overall survival rate in patients with breast cancer. These results provide a plausible mechanism for HER2-mediated breast tumor metastasis and establish a functional link between HER2 and CXCR4 signaling pathways.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Li YM,Pan Y,Wei Y,Cheng X,Zhou BP,Tan M,Zhou X,Xia W,Hortobagyi GN,Yu D,Hung MC

doi

10.1016/j.ccr.2004.09.027

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

459-69

issue

5

eissn

1535-6108

issn

1878-3686

pii

S1535610804003010

journal_volume

6

pub_type

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