Abstract:
:STAT3 plays many roles in tumorigenesis. In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine IL-23 in macrophages but inhibits the antitumor cytokine IL-12 in dendritic cells. STAT3 also mediates IL-23's effect of activating tumor-infiltrating regulatory T cells.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Stewart CA,Trinchieri Gdoi
10.1016/j.ccr.2009.01.008subject
Has Abstractpub_date
2009-02-03 00:00:00pages
81-3issue
2eissn
1535-6108issn
1878-3686pii
S1535-6108(09)00005-1journal_volume
15pub_type
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