Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression.

abstract：:Mutant RAS-driven tumorigenesis was thought for decades to arise independently of wild-type RAS isoforms, but recent evidence indicates wild-type isoforms are involved. In this issue of Cancer Cell, Grabocka and colleagues report how the loss of wild-type RAS alters oncogenic signaling and dampens the DNA-damage respo...

journal_title：Cancer cell

authors： Anastassiadis T,Brown EJ

更新日期：2014-02-10 00:00:00

abstract：:Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating ...

journal_title：Cancer cell

authors： Demir IE,Reyes CM,Alrawashdeh W,Ceyhan GO,Deborde S,Friess H,Görgülü K,Istvanffy R,Jungwirth D,Kuner R,Maryanovich M,Na'ara S,Renders S,Saloman JL,Scheff NN,Steenfadt H,Stupakov P,Thiel V,Verma D,Yilmaz BS,White R

更新日期：2020-07-13 00:00:00

abstract：:Obesity is a leading risk factor for cancer. However, understanding the crosstalk between adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in the field. Here we used a prostate cancer (PCa) mouse model in which the signaling adaptor p62/Sqstm1 is selectively inactivated in adi...

journal_title：Cancer cell

authors： Huang J,Duran A,Reina-Campos M,Valencia T,Castilla EA,Müller TD,Tschöp MH,Moscat J,Diaz-Meco MT

更新日期：2018-04-09 00:00:00

abstract：:A definitive knockout reported in this issue of Cancer Cell by Sicinska et al. reveals an unsuspected role for cyclin D3 in normal T cell development and suggests new therapeutic possibilities in precursor T cell leukemia. ...

journal_title：Cancer cell

authors： Weng AP,Aster JC

更新日期：2003-12-01 00:00:00

abstract：:To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-wide screen in yeast identified mitochondrial translation inhibition as the mechanism of tigecycline-mediated lethality. Tigecycline selective...

journal_title：Cancer cell

authors： Skrtić M,Sriskanthadevan S,Jhas B,Gebbia M,Wang X,Wang Z,Hurren R,Jitkova Y,Gronda M,Maclean N,Lai CK,Eberhard Y,Bartoszko J,Spagnuolo P,Rutledge AC,Datti A,Ketela T,Moffat J,Robinson BH,Cameron JH,Wrana J,Eaves

更新日期：2011-11-15 00:00:00

abstract：:To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples. Our analysis ident...

journal_title：Cancer cell

authors： Gruber TA,Larson Gedman A,Zhang J,Koss CS,Marada S,Ta HQ,Chen SC,Su X,Ogden SK,Dang J,Wu G,Gupta V,Andersson AK,Pounds S,Shi L,Easton J,Barbato MI,Mulder HL,Manne J,Wang J,Rusch M,Ranade S,Ganti R,Parker M,

更新日期：2012-11-13 00:00:00

abstract：:In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. The results suggest that ...

journal_title：Cancer cell

authors： Mederacke I,Schwabe RF

更新日期：2014-12-08 00:00:00

abstract：:Although signaling from phosphatidylinositol 3-kinase (PI3K) and AKT to mechanistic target of rapamycin (mTOR) is prominently dysregulated in high-grade glial brain tumors, blockade of PI3K or AKT minimally affects downstream mTOR activity in glioma. Allosteric mTOR inhibitors, such as rapamycin, incompletely block mT...

journal_title：Cancer cell

authors： Fan Q,Aksoy O,Wong RA,Ilkhanizadeh S,Novotny CJ,Gustafson WC,Truong AY,Cayanan G,Simonds EF,Haas-Kogan D,Phillips JJ,Nicolaides T,Okaniwa M,Shokat KM,Weiss WA

更新日期：2017-03-13 00:00:00

abstract：:Undifferentiated sarcomas (USARCs) of adults are diverse, rare, and aggressive soft tissue cancers. Recent sequencing efforts have confirmed that USARCs exhibit one of the highest burdens of structural aberrations across human cancer. Here, we sought to unravel the molecular basis of the structural complexity in USARC...

journal_title：Cancer cell

authors： Steele CD,Tarabichi M,Oukrif D,Webster AP,Ye H,Fittall M,Lombard P,Martincorena I,Tarpey PS,Collord G,Haase K,Strauss SJ,Berisha F,Vaikkinen H,Dhami P,Jansen M,Behjati S,Amary MF,Tirabosco R,Feber A,Campbell PJ,

更新日期：2019-03-18 00:00:00

abstract：:Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understandin...

journal_title：Cancer cell

authors： Wijewardhane N,Dressler L,Ciccarelli FD

更新日期：2020-11-17 00:00:00

abstract：:Slit is a secreted protein known to function through the Roundabout (Robo) receptor as a chemorepellent in axon guidance and neuronal migration, and as an inhibitor in leukocyte chemotaxis. Here we show Slit2 expression in a large number of solid tumors and Robo1 expression in vascular endothelial cells. Recombinant S...

journal_title：Cancer cell

authors： Wang B,Xiao Y,Ding BB,Zhang N,Yuan Xb,Gui L,Qian KX,Duan S,Chen Z,Rao Y,Geng JG

更新日期：2003-07-01 00:00:00

abstract：:The receptor tyrosine kinase HER2 enhances tumor metastasis; however, its role in homing to metastatic organs is poorly understood. The chemokine receptor CXCR4 has recently been shown to mediate the movement of malignant cancer cells to specific organs. Here, we show that HER2 enhances the expression of CXCR4, which ...

journal_title：Cancer cell

authors： Li YM,Pan Y,Wei Y,Cheng X,Zhou BP,Tan M,Zhou X,Xia W,Hortobagyi GN,Yu D,Hung MC

更新日期：2004-11-01 00:00:00

abstract：:The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that antiangiogenic therapy must be combined with cytotoxic therapy for the treatment of solid tumors. However, there are no guidelines for optimal scheduling of these therapies. Here we show that VEGFR2 blockade creates a "normalizati...

journal_title：Cancer cell

authors： Winkler F,Kozin SV,Tong RT,Chae SS,Booth MF,Garkavtsev I,Xu L,Hicklin DJ,Fukumura D,di Tomaso E,Munn LL,Jain RK

更新日期：2004-12-01 00:00:00

abstract：:Here, we show that tumor ADORA1 deletion suppresses cell growth in human melanoma cell lines in vitro and tumor development in vivo in immune-deficient xenografts. However, this deletion induces the upregulation of PD-L1 levels, which inactivates cocultured T cells in vitro, compromises anti-tumor immunity in vivo, an...

journal_title：Cancer cell

authors： Liu H,Kuang X,Zhang Y,Ye Y,Li J,Liang L,Xie Z,Weng L,Guo J,Li H,Ma F,Chen X,Zhao S,Su J,Yang N,Fang F,Xie Y,Tao J,Zhang J,Chen M,Peng C,Sun L,Zhang X,Liu J,Han L,Xu X,Hung MC,Chen X

更新日期：2020-03-16 00:00:00

abstract：:STAT3 plays many roles in tumorigenesis. In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine IL-23 in macrophages but inhibits the antitumor cytokine IL-12 in dendritic cells. STAT3 also mediates IL-23's effect of activating t...

journal_title：Cancer cell

authors： Stewart CA,Trinchieri G

更新日期：2009-02-03 00:00:00

abstract：:Inhibition of ERK-MAPK signaling by expression of dominant-negative MEK1 in the tumor vasculature suppresses angiogenesis and tumor growth. In an organotypic tissue culture angiogenesis assay, ERK-MAPK inhibition during the migratory phase results in loss of bipolarity, detachment, and cell death of isolated endotheli...

journal_title：Cancer cell

authors： Mavria G,Vercoulen Y,Yeo M,Paterson H,Karasarides M,Marais R,Bird D,Marshall CJ

更新日期：2006-01-01 00:00:00

abstract：:Amino acid (AA) is a potent mitogen that controls growth and metabolism. Here we describe the identification of Rab1 as a conserved regulator of AA signaling to mTORC1. AA stimulates Rab1A GTP binding and interaction with mTORC1 and Rheb-mTORC1 interaction in the Golgi. Rab1A overexpression promotes mTORC1 signaling a...

journal_title：Cancer cell

authors： Thomas JD,Zhang YJ,Wei YH,Cho JH,Morris LE,Wang HY,Zheng XF

更新日期：2014-11-10 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) initiated by expression of the p210-BCR-ABL fusion protein. We demonstrate in a murine model of p210-BCR-ABL-induced MPD that gene targeting of Rac1 and Rac2 significantly delays or abrogates disease development. Attenuation of the disease...

journal_title：Cancer cell

authors： Thomas EK,Cancelas JA,Chae HD,Cox AD,Keller PJ,Perrotti D,Neviani P,Druker BJ,Setchell KD,Zheng Y,Harris CE,Williams DA

更新日期：2007-11-01 00:00:00

abstract：:We demonstrate that concurrent administration of poly(ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly tolerated. Concurrent treatment with PARP and WEE1 inhibitors induces replication stress, DNA damage, and abrogates the G2 DNA damage checkpoint in both normal and ...

journal_title：Cancer cell

authors： Fang Y,McGrail DJ,Sun C,Labrie M,Chen X,Zhang D,Ju Z,Vellano CP,Lu Y,Li Y,Jeong KJ,Ding Z,Liang J,Wang SW,Dai H,Lee S,Sahni N,Mercado-Uribe I,Kim TB,Chen K,Lin SY,Peng G,Westin SN,Liu J,O'Connor MJ,Yap T

更新日期：2019-06-10 00:00:00

abstract：:Ras and pRb are key regulators of a plethora of cellular processes, including proliferation, differentiation, and tumorigenesis. Adding to several previously established lines of communication between the two, in this issue of Cancer Cell, Shamma et al. resolve a new signaling network involved in cellular senescence a...

journal_title：Cancer cell

authors： Peeper DS

更新日期：2009-04-07 00:00:00

abstract：:A specific association with mixed lineage leukemias suggests that MLL oncoproteins may selectively target early multipotent hematopoietic progenitors or stem cells. We demonstrate here that a representative MLL fusion protein, MLL-GAS7, impairs the differentiation and enhances the in vitro growth of murine hematopoiet...

journal_title：Cancer cell

authors： So CW,Karsunky H,Passegué E,Cozzio A,Weissman IL,Cleary ML

更新日期：2003-02-01 00:00:00

abstract：:We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas. We demonstrated that cancer subtypes and ancestry-related technical artifacts are important confounders that have been insufficiently accounted for....

journal_title：Cancer cell

authors： Carrot-Zhang J,Chambwe N,Damrauer JS,Knijnenburg TA,Robertson AG,Yau C,Zhou W,Berger AC,Huang KL,Newberg JY,Mashl RJ,Romanel A,Sayaman RW,Demichelis F,Felau I,Frampton GM,Han S,Hoadley KA,Kemal A,Laird PW,Lazar AJ

更新日期：2020-05-11 00:00:00

abstract：:Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from i...

journal_title：Cancer cell

authors： Wu S,Mischel PS

更新日期：2020-09-14 00:00:00

abstract：:Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now underst...

journal_title：Cancer cell

authors： Schmitt AM,Chang HY

更新日期：2016-04-11 00:00:00

abstract：:Through in silico and other analyses, we identified FOXC1 as expressed in at least 20% of human AML cases, but not in normal hematopoietic populations. FOXC1 expression in AML was almost exclusively associated with expression of the HOXA/B locus. Functional experiments demonstrated that FOXC1 contributes to a block in...

journal_title：Cancer cell

authors： Somerville TD,Wiseman DH,Spencer GJ,Huang X,Lynch JT,Leong HS,Williams EL,Cheesman E,Somervaille TC

更新日期：2015-09-14 00:00:00

abstract：:Benign neurofibromas and malignant peripheral nerve sheath tumors are serious complications of neurofibromatosis type 1. The epidermal growth factor receptor is not expressed by normal Schwann cells, yet is overexpressed in subpopulations of Nf1 mutant Schwann cells. We evaluated the role of EGFR in Schwann cell tumor...

journal_title：Cancer cell

authors： Ling BC,Wu J,Miller SJ,Monk KR,Shamekh R,Rizvi TA,Decourten-Myers G,Vogel KS,DeClue JE,Ratner N

更新日期：2005-01-01 00:00:00

abstract：:One of the biggest challenges in treating acute myeloid leukemia (AML) is relapse of aggressive disease after treatment. In this issue of Cancer Cell, Boyd et al. characterize a molecularly distinct population of chemotherapy-induced transient leukemic regenerating cells (LRCs), which can be exploited to prevent AML r...

journal_title：Cancer cell

authors： Vu LP,Kharas MG

更新日期：2018-09-10 00:00:00

abstract：:Mutational activation of KRas is the first and most frequently detected genetic lesion in pancreatic ductal adenocarcinoma (PDAC). However, the precise role of oncogenic KRas in the pathogenesis of PDAC is not fully understood. Here, we report that the endogenous expression of oncogenic KRas suppresses premature senes...

journal_title：Cancer cell

authors： Lee KE,Bar-Sagi D

更新日期：2010-11-16 00:00:00

abstract：:To investigate the role of signaling by the small GTPase Ral, we have generated mice deficient for RalGDS, a guanine nucleotide exchange factor that activates Ral. We show that RalGDS is dispensable for mouse development but plays a substantial role in Ras-induced oncogenesis. Lack of RalGDS results in reduced tumor i...

journal_title：Cancer cell

authors： González-García A,Pritchard CA,Paterson HF,Mavria G,Stamp G,Marshall CJ

更新日期：2005-03-01 00:00:00

abstract：:Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e.g., T cell lymphoma (TCL). Here, Ca2+/calmodulin-dependent protein kinase II γ (CAMKIIγ) was shown to stabilize the c-Myc protein by direct...

journal_title：Cancer cell

authors： Gu Y,Zhang J,Ma X,Kim BW,Wang H,Li J,Pan Y,Xu Y,Ding L,Yang L,Guo C,Wu X,Wu J,Wu K,Gan X,Li G,Li L,Forman SJ,Chan WC,Xu R,Huang W

更新日期：2017-07-10 00:00:00