Abstract:
:Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Schmitt AM,Chang HYdoi
10.1016/j.ccell.2016.03.010subject
Has Abstractpub_date
2016-04-11 00:00:00pages
452-463issue
4eissn
1535-6108issn
1878-3686pii
S1535-6108(16)30092-7journal_volume
29pub_type
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