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Kidney cancer: now available in a new flavor.

Abstract：

:The role of the von Hippel-Lindau tumor suppressor protein (pVHL) in kidney cancer has provided a rationale for treating this disease with hypoxia-inducible factor (HIF) antagonists. In this issue, Simon and coworkers show that the molecular signature of VHL(-/-) kidney cancers is profoundly influenced by whether they produce both HIF2alpha and HIF1alpha or HIF2alpha alone.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Kaelin WG Jr

doi

10.1016/j.ccr.2008.11.005

subject

Has Abstract

pub_date

2008-12-09 00:00:00

pages

423-4

issue

6

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(08)00372-3

journal_volume

14

pub_type

评论,杂志文章

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