Abstract：
:Ras proteins play a major role in human cancers but have not yielded to therapeutic attack. Ras-driven cancers are among the most difficult to treat and often excluded from therapies. The Ras proteins have been termed "undruggable," based on failures from an era in which understanding of signaling transduction, feedback loops, redundancy, tumor heterogeneity, and Ras' oncogenic role was poor. Structures of Ras oncoproteins bound to their effectors or regulators are unsolved, and it is unknown precisely how Ras proteins activate their downstream targets. These knowledge gaps have impaired development of therapeutic strategies. A better understanding of Ras biology and biochemistry, coupled with new ways of targeting undruggable proteins, is likely to lead to new ways of defeating Ras-driven cancers.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Stephen AG,Esposito D,Bagni RK,McCormick Fdoi
10.1016/j.ccr.2014.02.017subject
Has Abstractpub_date
2014-03-17 00:00:00pages
272-81issue
3eissn
1535-6108issn
1878-3686pii
S1535-6108(14)00081-6journal_volume
25pub_type
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