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Senesce to Survive: YAP-Mediated Dormancy Escapes EGFR/MEK Inhibition.

Abstract：

:Therapeutic resistance is a major challenge in cancer treatment. In this issue of Cancer Cell, Kurppa et al. demonstrated that a senescence-like state enables lung cancer cells to survive dual inhibition of EGFR and MEK. This was mediated by the YAP/TEAD pathway, which drives epigenomic reprogramming and EMT to counteract apoptosis.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Bado I,Zhang XH

doi

10.1016/j.ccell.2019.12.008

subject

Has Abstract

pub_date

2020-01-13 00:00:00

pages

1-2

issue

1

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(19)30578-1

journal_volume

37

pub_type

评论,杂志文章

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