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Methylome alterations "mark" new therapeutic opportunities in glioblastoma.

Abstract：

:In this issue of Cancer Cell, Sturm et al. report that global DNA methylation patterns in glioblastoma multiforme divide adult and pediatric tumors into subgroups that have characteristic DNA mutations, mRNA profiles, and most importantly, different clinical behaviors. These findings suggest novel opportunities for therapeutics for this dreaded disease.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Raabe EH,Eberhart CG

doi

10.1016/j.ccr.2012.10.001

subject

Has Abstract

pub_date

2012-10-16 00:00:00

pages

417-8

issue

4

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(12)00403-5

journal_volume

22

pub_type

评论,杂志文章

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