Abstract:
:Myeloid-derived suppressor cells (MDSCs) play a major role in cancer. MDSC expansion is closely associated with tumor progression, but molecular mechanisms of this expansion remain poorly understood. In this issue of Cancer Cell, Strauss and colleagues describe the roles of the nuclear receptor ROR1C in the regulation of MDSC differentiation and expansion.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Gabrilovich D,Nefedova Ydoi
10.1016/j.ccell.2015.07.007subject
Has Abstractpub_date
2015-08-10 00:00:00pages
147-9issue
2eissn
1535-6108issn
1878-3686pii
S1535-6108(15)00259-7journal_volume
28pub_type
评论,杂志文章相关文献
CANCER CELL文献大全abstract::Beta-catenin and Tcf4 are the downstream effectors of the Wnt signaling cascade. In colorectal cancer, mutations in Wnt cascade genes such as APC lead to the inappropriate formation of beta-catenin/Tcf4 complexes. Earlier work has predicted that disruption of the beta-catenin/Tcf4 protein-protein interaction could rev...
journal_title:Cancer cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s1535-6108(03)00339-8
更新日期:2004-01-01 00:00:00
abstract::The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increased ROS in PDAC cel...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2019.12.012
更新日期:2020-02-10 00:00:00
abstract::Genital human papillomavirus (HPV) infection is causally linked to the development of cervical cancer, a leading cause of cancer-related mortality in women worldwide. Recent studies demonstrate the effectiveness of virus-like particle-based vaccines to induce neutralizing antibodies against HPV and prevent cervical in...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(02)00239-8
更新日期:2003-01-01 00:00:00
abstract::Undifferentiated sarcomas (USARCs) of adults are diverse, rare, and aggressive soft tissue cancers. Recent sequencing efforts have confirmed that USARCs exhibit one of the highest burdens of structural aberrations across human cancer. Here, we sought to unravel the molecular basis of the structural complexity in USARC...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2019.02.002
更新日期:2019-03-18 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations in distinct cell types of the adult pancreas. We show that a subpopulation of Pdx1-expressing cells is susceptible to onco...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.09.027
更新日期:2009-11-06 00:00:00
abstract::The TFAP2C/AP-2γ transcription factor regulates luminal breast cancer genes, and loss of TFAP2C induces epithelial-mesenchymal transition. By contrast, the highly homologous family member, TFAP2A, lacks transcriptional activity at luminal gene promoters. A detailed structure-function analysis identified that sumoylati...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2014.04.008
更新日期:2014-06-16 00:00:00
abstract::Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for react...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.08.020
更新日期:2012-09-11 00:00:00
abstract::Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2007.05.004
更新日期:2007-06-01 00:00:00
abstract::The erythroleukemia developed by spi-1/PU.1 transgenic mice is a multistage process characterized by an early arrest of the proerythroblast differentiation followed later on by malignant transformation. Herein, we report the presence of acquired mutations in the SCF receptor gene (Kit) in 86% of tumors isolated during...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.11.009
更新日期:2005-12-01 00:00:00
abstract::Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understandin...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.11.002
更新日期:2020-11-17 00:00:00
abstract::Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from i...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.08.012
更新日期:2020-09-14 00:00:00
abstract::The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent chromatin domains at critical germinal center (GC) B cell promoters. Herein we show that the actions of EZH2 in driving GC formation and lymphoma precursor lesions require site-specific bind...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.07.006
更新日期:2016-08-08 00:00:00
abstract::Mutational activation of KRas is the first and most frequently detected genetic lesion in pancreatic ductal adenocarcinoma (PDAC). However, the precise role of oncogenic KRas in the pathogenesis of PDAC is not fully understood. Here, we report that the endogenous expression of oncogenic KRas suppresses premature senes...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2010.10.020
更新日期:2010-11-16 00:00:00
abstract::In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. The results suggest that ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2014.11.011
更新日期:2014-12-08 00:00:00
abstract::The hedgehog (Hh) signaling pathway plays many roles in invertebrate and vertebrate development. For example, specific inhibition of sonic Hh expression is critical during early stages of pancreas organogenesis, but an active Hh pathway appears to be required for maintenance of adult endocrine functions. Mutational in...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(03)00246-0
更新日期:2003-10-01 00:00:00
abstract::E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukem...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.06.006
更新日期:2016-07-11 00:00:00
abstract::In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 statu...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.04.010
更新日期:2016-05-09 00:00:00
abstract::Drug delivery systems for cancer therapeutics have now been used by millions of patients and have resulted in the creation of new therapies as well as significantly improving existing ones. Here we discuss a number of the drug delivery systems that have been approved by regulatory authorities and that are currently in...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(03)00276-9
更新日期:2003-11-01 00:00:00
abstract::Homeobox domain-containing transcription factors are important regulators of hematopoiesis. Here, we report that increased levels of nonclustered H2.0-like homeobox (HLX) lead to loss of functional hematopoietic stem cells and formation of aberrant progenitors with unlimited serial clonogenicity and blocked differenti...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.06.027
更新日期:2012-08-14 00:00:00
abstract::The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that antiangiogenic therapy must be combined with cytotoxic therapy for the treatment of solid tumors. However, there are no guidelines for optimal scheduling of these therapies. Here we show that VEGFR2 blockade creates a "normalizati...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2004.10.011
更新日期:2004-12-01 00:00:00
abstract::HIF-2alpha promotes von Hippel-Lindau (VHL)-deficient renal clear cell carcinoma (RCC) tumorigenesis, while HIF-1alpha inhibits RCC growth. As HIF-1alpha antagonizes c-Myc function, we hypothesized that HIF-2alpha might enhance c-Myc activity. We demonstrate here that HIF-2alpha promotes cell-cycle progression in hypo...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2007.02.006
更新日期:2007-04-01 00:00:00
abstract::Transcription factor NF-kappaB has been implicated in cancer development due to its ability to upregulate expression of genes with potentially prooncogenic functions, such as cell cycle regulators and antiapoptotic proteins (Karin et al., 2002). A recent report by suggests that a structural motif, a death domain (DD),...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(02)00213-1
更新日期:2002-12-01 00:00:00
abstract::The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggabl...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.11.017
更新日期:2017-12-11 00:00:00
abstract::Human T cell leukemias can arise from oncogenes activated by specific chromosomal translocations involving the T cell receptor genes. Here we show that five different T cell oncogenes (HOX11, TAL1, LYL1, LMO1, and LMO2) are often aberrantly expressed in the absence of chromosomal abnormalities. Using oligonucleotide m...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(02)00018-1
更新日期:2002-02-01 00:00:00
abstract::8p11 myeloproliferative syndrome (EMS) is a hematopoietic stem cell disorder characterized by myeloid hyperplasia and non-Hodgkin's lymphoma with chromosomal translocations fusing several genes, most commonly ZNF198, to fibroblast growth factor receptor-1 (FGFR1). However, patients with BCR-FGFR1 fusion present with t...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(04)00053-4
更新日期:2004-03-01 00:00:00
abstract::Neuropilin-1 (NRP1) guides the development of the nervous and vascular systems. Binding to either semaphorins or VEGF, NRP1 acts with plexins to regulate neuronal guidance, or with VEGFR2 to mediate vascular development. We have generated two monoclonal antibodies that bind to the Sema- and VEGF-binding domains of NRP...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.10.018
更新日期:2007-01-01 00:00:00
abstract::We used small molecule screening to discover compounds and mechanisms for overcoming E6 oncogene-mediated drug resistance. Using high-throughput screening in isogenic cell lines, we identified compounds that potentiate doxorubicin's lethality in E6-expressing colon cancer cells. Such compounds included quaternary ammo...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.01.012
更新日期:2006-02-01 00:00:00
abstract::PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation PIK3R1(R348∗) and a nearby mutation PIK3R1(L370fs), in contrast to wild-type and mutations in other regions of PIK3R1, confers an unexpected sensitivity to MEK an...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.08.017
更新日期:2014-10-13 00:00:00
abstract::The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways. Here, we report that conditional ablation of TAK1 in liver parenchymal cells (hepatocytes and cholangiocytes) causes hepatoc...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2010.03.021
更新日期:2010-05-18 00:00:00
abstract::Rapamycin analogs that inhibit mTOR signaling have antitumor activity against certain lymphomas, but treatment of solid tumors has been less encouraging despite inhibition of mTOR function. Two recent papers give insight into the potential use of mTOR inhibitors. O'Reilly et al. provide evidence that poor tumor respon...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccr.2006.02.027
更新日期:2006-03-01 00:00:00