Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage.

abstract：:The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs). Silencing ALKBH5 suppresses the proliferation ...

journal_title：Cancer cell

authors： Zhang S,Zhao BS,Zhou A,Lin K,Zheng S,Lu Z,Chen Y,Sulman EP,Xie K,Bögler O,Majumder S,He C,Huang S

更新日期：2017-04-10 00:00:00

abstract：:Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations result in the acquisition of stem cell-like features, overexpression of adhesion molecules causi...

journal_title：Cancer cell

authors： Churchman ML,Qian M,Te Kronnie G,Zhang R,Yang W,Zhang H,Lana T,Tedrick P,Baskin R,Verbist K,Peters JL,Devidas M,Larsen E,Moore IM,Gu Z,Qu C,Yoshihara H,Porter SN,Pruett-Miller SM,Wu G,Raetz E,Martin PL,Bowman

更新日期：2018-05-14 00:00:00

abstract：:Van den Eynde et al. publish in this issue of Cancer Cell that metastatic colorectal cancer shows marked heterogeneity in T cell infiltration among different lesions and patients. Measurements of T cell infiltration in metastases by immunoscore offer some prognostic information and support immune editing by coevolving...

journal_title：Cancer cell

authors： de Andrea CE,Schalper KA,Sanmamed MF,Melero I

更新日期：2018-12-10 00:00:00

abstract：:Unresponsiveness to therapy is a hallmark feature of advanced metastatic melanoma. However, the discovery of BRAF-activating mutations in approximately 50% of human melanomas has provided an attractive therapeutic target. Here, we discuss two recent publications focusing on the mutant BRAF kinase inhibitor PLX4032 tha...

journal_title：Cancer cell

authors： Vultur A,Villanueva J,Herlyn M

更新日期：2010-10-19 00:00:00

abstract：:Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a...

journal_title：Cancer cell

authors： Zheng T,Ménard M,Weiss WA

更新日期：2017-10-09 00:00:00

abstract：:Gankyrin is an ankyrin repeat oncoprotein commonly overexpressed in hepatocellular carcinomas. Gankyrin interacts with the S6 proteasomal ATPase and accelerates the degradation of the tumor suppressor Rb. We show here that gankyrin has an antiapoptotic activity in cells exposed to DNA damaging agents. Downregulation o...

journal_title：Cancer cell

authors： Higashitsuji H,Higashitsuji H,Itoh K,Sakurai T,Nagao T,Sumitomo Y,Masuda T,Dawson S,Shimada Y,Mayer RJ,Fujita J

更新日期：2005-07-01 00:00:00

abstract：:Breast cancer is a heterogeneous disease and can be classified based on gene expression profiles that reflect distinct epithelial subtypes. We identify prostate-derived ETS factor (PDEF) as a mediator of mammary luminal epithelial lineage-specific gene expression and as a factor required for tumorigenesis in a subset ...

journal_title：Cancer cell

authors： Buchwalter G,Hickey MM,Cromer A,Selfors LM,Gunawardane RN,Frishman J,Jeselsohn R,Lim E,Chi D,Fu X,Schiff R,Brown M,Brugge JS

更新日期：2013-06-10 00:00:00

abstract：:HIF-2alpha promotes von Hippel-Lindau (VHL)-deficient renal clear cell carcinoma (RCC) tumorigenesis, while HIF-1alpha inhibits RCC growth. As HIF-1alpha antagonizes c-Myc function, we hypothesized that HIF-2alpha might enhance c-Myc activity. We demonstrate here that HIF-2alpha promotes cell-cycle progression in hypo...

journal_title：Cancer cell

authors： Gordan JD,Bertout JA,Hu CJ,Diehl JA,Simon MC

更新日期：2007-04-01 00:00:00

abstract：:Tumors constitute highly suppressive microenvironments in which infiltrating T cells are "exhausted" by inhibitory receptors such as PD-1. Here we identify TIGIT as a coinhibitory receptor that critically limits antitumor and other CD8(+) T cell-dependent chronic immune responses. TIGIT is highly expressed on human an...

journal_title：Cancer cell

authors： Johnston RJ,Comps-Agrar L,Hackney J,Yu X,Huseni M,Yang Y,Park S,Javinal V,Chiu H,Irving B,Eaton DL,Grogan JL

更新日期：2014-12-08 00:00:00

abstract：:Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX loci as hematopoietic cells mature, thus coinciding with a decrease in HOX gene expression. We show that H3K79 methyltrans...

journal_title：Cancer cell

authors： Deshpande AJ,Deshpande A,Sinha AU,Chen L,Chang J,Cihan A,Fazio M,Chen CW,Zhu N,Koche R,Dzhekieva L,Ibáñez G,Dias S,Banka D,Krivtsov A,Luo M,Roeder RG,Bradner JE,Bernt KM,Armstrong SA

更新日期：2014-12-08 00:00:00

abstract：:To identify regulatory drivers of prostate cancer malignancy, we have assembled genome-wide regulatory networks (interactomes) for human and mouse prostate cancer from expression profiles of human tumors and of genetically engineered mouse models, respectively. Cross-species computational analysis of these interactome...

journal_title：Cancer cell

authors： Aytes A,Mitrofanova A,Lefebvre C,Alvarez MJ,Castillo-Martin M,Zheng T,Eastham JA,Gopalan A,Pienta KJ,Shen MM,Califano A,Abate-Shen C

更新日期：2014-05-12 00:00:00

abstract：:Heterozygous somatic mutations in the spliceosome gene U2AF1 occur in ∼ 11% of patients with myelodysplastic syndromes (MDS), the most common adult myeloid malignancy. It is unclear how these mutations contribute to disease. We examined in vivo hematopoietic consequences of the most common U2AF1 mutation using a doxyc...

journal_title：Cancer cell

authors： Shirai CL,Ley JN,White BS,Kim S,Tibbitts J,Shao J,Ndonwi M,Wadugu B,Duncavage EJ,Okeyo-Owuor T,Liu T,Griffith M,McGrath S,Magrini V,Fulton RS,Fronick C,O'Laughlin M,Graubert TA,Walter MJ

更新日期：2015-05-11 00:00:00

abstract：:In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. The results suggest that ...

journal_title：Cancer cell

authors： Mederacke I,Schwabe RF

更新日期：2014-12-08 00:00:00

abstract：:Mutations in VHL, RET, NF1, SDHB, SDHC, and SDHD can give rise to pheochromocytoma/paraganglioma. These different genetic lesions may all act by decreasing the activity of a 2-oxoglutarate-dependent oxygenase, SM-20/EglN3/PHD3, resulting in reduced apoptosis of neural crest cells during development. ...

journal_title：Cancer cell

authors： Maxwell PH

更新日期：2005-08-01 00:00:00

abstract：:Amino acid (AA) is a potent mitogen that controls growth and metabolism. Here we describe the identification of Rab1 as a conserved regulator of AA signaling to mTORC1. AA stimulates Rab1A GTP binding and interaction with mTORC1 and Rheb-mTORC1 interaction in the Golgi. Rab1A overexpression promotes mTORC1 signaling a...

journal_title：Cancer cell

authors： Thomas JD,Zhang YJ,Wei YH,Cho JH,Morris LE,Wang HY,Zheng XF

更新日期：2014-11-10 00:00:00

abstract：:p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs). Although p62 was proposed to participate in the formation of benign adenomas in autophagy-deficient livers, its role in HCC initiation was not explored. Here we...

journal_title：Cancer cell

authors： Umemura A,He F,Taniguchi K,Nakagawa H,Yamachika S,Font-Burgada J,Zhong Z,Subramaniam S,Raghunandan S,Duran A,Linares JF,Reina-Campos M,Umemura S,Valasek MA,Seki E,Yamaguchi K,Koike K,Itoh Y,Diaz-Meco MT,Moscat J,K

更新日期：2016-06-13 00:00:00

abstract：:Deregulation of E2F1 activity and resistance to TGFbeta are hallmarks of gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs frequently misregulated in human malignancies. Here we provide evidence that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel wi...

journal_title：Cancer cell

authors： Petrocca F,Visone R,Onelli MR,Shah MH,Nicoloso MS,de Martino I,Iliopoulos D,Pilozzi E,Liu CG,Negrini M,Cavazzini L,Volinia S,Alder H,Ruco LP,Baldassarre G,Croce CM,Vecchione A

更新日期：2008-03-01 00:00:00

abstract：:Even in the presence of an adequate oxygen supply, many tumors metabolize the majority of the glucose they take up through glycolysis. It has been a long-held belief that this glycolytic phenotype is due to cancer-specific defects in mitochondrial oxidative phosphorylation. In this issue of Cancer Cell, Fantin et al. ...

journal_title：Cancer cell

authors： Bui T,Thompson CB

更新日期：2006-06-01 00:00:00

abstract：:Activating mutations in the FLT3 receptor tyrosine kinase occur in 30% of patients with acute myeloid leukemia. Small molecule FLT3 kinase inhibitors show selective antitumor activity in preclinical models. Clinical studies are underway. ...

journal_title：Cancer cell

authors： Sawyers CL

更新日期：2002-06-01 00:00:00

abstract：:We used small molecule screening to discover compounds and mechanisms for overcoming E6 oncogene-mediated drug resistance. Using high-throughput screening in isogenic cell lines, we identified compounds that potentiate doxorubicin's lethality in E6-expressing colon cancer cells. Such compounds included quaternary ammo...

journal_title：Cancer cell

authors： Smukste I,Bhalala O,Persico M,Stockwell BR

更新日期：2006-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms underlying NASH and NASH-induced HCC are largely unknown. We developed a mouse model recapitulating key features of human metabolic syndrome, NASH, ...

journal_title：Cancer cell

authors： Wolf MJ,Adili A,Piotrowitz K,Abdullah Z,Boege Y,Stemmer K,Ringelhan M,Simonavicius N,Egger M,Wohlleber D,Lorentzen A,Einer C,Schulz S,Clavel T,Protzer U,Thiele C,Zischka H,Moch H,Tschöp M,Tumanov AV,Haller D,Ung

更新日期：2014-10-13 00:00:00

abstract：:The BCL6 gene is a key factor necessary for formation of germinal centers and is implicated in pathogenesis of diffuse large B cell lymphoma (DLBCL). In this issue of Cancer Cell, Saito and colleagues explore regulation of BCL6 gene expression by CD40-NF-kappaB signaling pathway and show that the IRF4 transcriptional ...

journal_title：Cancer cell

authors： Lossos IS

更新日期：2007-09-01 00:00:00

abstract：:Oncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor vascular endothelial cells. We show here that this expanded tropism of oncolytic vaccinia virus to the endothelial compartment is a consequence of VEGF-mediated suppression of the intrinsic antiviral response. VEGF/VEGFR2 sig...

journal_title：Cancer cell

authors： Arulanandam R,Batenchuk C,Angarita FA,Ottolino-Perry K,Cousineau S,Mottashed A,Burgess E,Falls TJ,De Silva N,Tsang J,Howe GA,Bourgeois-Daigneault MC,Conrad DP,Daneshmand M,Breitbach CJ,Kirn DH,Raptis L,Sad S,Atkins H

更新日期：2015-08-10 00:00:00

abstract：:A specific association with mixed lineage leukemias suggests that MLL oncoproteins may selectively target early multipotent hematopoietic progenitors or stem cells. We demonstrate here that a representative MLL fusion protein, MLL-GAS7, impairs the differentiation and enhances the in vitro growth of murine hematopoiet...

journal_title：Cancer cell

authors： So CW,Karsunky H,Passegué E,Cozzio A,Weissman IL,Cleary ML

更新日期：2003-02-01 00:00:00

abstract：:The role of Lyn, both a positive and a negative regulator of B and myeloid cells, in chronic lymphocytic leukemia (CLL) has not been well characterized. In this issue of Cancer Cell, Nguyen et al. demonstrated that Lyn in macrophages rather than in CLL cells is critical for the malignancy. ...

journal_title：Cancer cell

authors： Dong S,Byrd JC

更新日期：2016-10-10 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations in distinct cell types of the adult pancreas. We show that a subpopulation of Pdx1-expressing cells is susceptible to onco...

journal_title：Cancer cell

authors： Gidekel Friedlander SY,Chu GC,Snyder EL,Girnius N,Dibelius G,Crowley D,Vasile E,DePinho RA,Jacks T

更新日期：2009-11-06 00:00:00

abstract：:PPARgamma is a member of the nuclear receptor family for which agonist ligands have antigrowth effects. However, clinical studies using PPARgamma ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARgamma activation with chemotherapeutic agents in current use for specifi...

journal_title：Cancer cell

authors： Girnun GD,Naseri E,Vafai SB,Qu L,Szwaya JD,Bronson R,Alberta JA,Spiegelman BM

更新日期：2007-05-01 00:00:00

abstract：:Transcription factor NF-kappaB has been implicated in cancer development due to its ability to upregulate expression of genes with potentially prooncogenic functions, such as cell cycle regulators and antiapoptotic proteins (Karin et al., 2002). A recent report by suggests that a structural motif, a death domain (DD),...

journal_title：Cancer cell

authors： Häcker H,Karin M

更新日期：2002-12-01 00:00:00

abstract：:Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating ...

journal_title：Cancer cell

authors： Demir IE,Reyes CM,Alrawashdeh W,Ceyhan GO,Deborde S,Friess H,Görgülü K,Istvanffy R,Jungwirth D,Kuner R,Maryanovich M,Na'ara S,Renders S,Saloman JL,Scheff NN,Steenfadt H,Stupakov P,Thiel V,Verma D,Yilmaz BS,White R

更新日期：2020-07-13 00:00:00

abstract：:Two recent Lancet and Lancet Oncology papers report that cancer patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have higher mortality rates. Common independent factors associated with increased risk of death were older age, history of smoking status, number of comorbidities, more a...

journal_title：Cancer cell

authors： Curigliano G

更新日期：2020-08-10 00:00:00