Abstract:
:Mutations in VHL, RET, NF1, SDHB, SDHC, and SDHD can give rise to pheochromocytoma/paraganglioma. These different genetic lesions may all act by decreasing the activity of a 2-oxoglutarate-dependent oxygenase, SM-20/EglN3/PHD3, resulting in reduced apoptosis of neural crest cells during development.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Maxwell PHdoi
10.1016/j.ccr.2005.07.012keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
91-3issue
2eissn
1535-6108issn
1878-3686pii
S1535-6108(05)00233-3journal_volume
8pub_type
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