Abstract：
:We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Mun DG,Bhin J,Kim S,Kim H,Jung JH,Jung Y,Jang YE,Park JM,Kim H,Jung Y,Lee H,Bae J,Back S,Kim SJ,Kim J,Park H,Li H,Hwang KB,Park YS,Yook JH,Kim BS,Kwon SY,Ryu SW,Park DY,Jeon TY,Kim DH,Lee JH,Han SU,doi
10.1016/j.ccell.2018.12.003subject
Has Abstractpub_date
2019-01-14 00:00:00pages
111-124.e10issue
1eissn
1535-6108issn
1878-3686pii
S1535-6108(18)30574-9journal_volume
35pub_type
杂志文章相关文献
CANCER CELL文献大全abstract：:The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that antiangiogenic therapy must be combined with cytotoxic therapy for the treatment of solid tumors. However, there are no guidelines for optimal scheduling of these therapies. Here we show that VEGFR2 blockade creates a "normalizati...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2004.10.011
更新日期：2004-12-01 00:00:00
abstract：:T cell engineering is a powerful means to rapidly generate anti-tumor T cells. The costimulatory properties of second-generation chimeric antigen receptors (CARs) determine the overall potency of adoptively transferred T cells. Using an in vivo "stress test" to challenge CD19-targeted T cells, we studied the functiona...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2015.09.004
更新日期：2015-10-12 00:00:00
abstract：:Here, we show that tumor ADORA1 deletion suppresses cell growth in human melanoma cell lines in vitro and tumor development in vivo in immune-deficient xenografts. However, this deletion induces the upregulation of PD-L1 levels, which inactivates cocultured T cells in vitro, compromises anti-tumor immunity in vivo, an...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2020.02.006
更新日期：2020-03-16 00:00:00
abstract：:The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increased ROS in PDAC cel...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2019.12.012
更新日期：2020-02-10 00:00:00
abstract：:The hedgehog (Hh) signaling pathway plays many roles in invertebrate and vertebrate development. For example, specific inhibition of sonic Hh expression is critical during early stages of pancreas organogenesis, but an active Hh pathway appears to be required for maintenance of adult endocrine functions. Mutational in...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/s1535-6108(03)00246-0
更新日期：2003-10-01 00:00:00
abstract：:Antiangiogenic tumor therapy has failed in the adjuvant setting. Here we show that inhibition of the Tie2 ligand angiopoietin-2 (Ang2) effectively blocks metastatic growth in preclinical mouse models of postsurgical adjuvant therapy. Ang2 antibody treatment combines well with low-dose metronomic chemotherapy (LDMC) in...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2014.11.005
更新日期：2014-12-08 00:00:00
abstract：:Chimeric antigen receptor (CAR) therapy targeting CD19 has yielded remarkable outcomes in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute myeloid leukemia (AML), we probed the AML surfaceome for overexpressed molecules with tolerable systemic expression. We integrated large trans...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2017.09.004
更新日期：2017-10-09 00:00:00
abstract：:Specific phosphoinositide lipids promote cell growth and cancer. In this issue of Cancer Cell, Fayngerts and colleagues demonstrate that the TIPE3 protein enhances PtdIns(4,5)P2 and PtdIns(3,4,5)P3, is overexpressed in certain cancers, and promotes tumorigenesis. TIPE3 can act as a lipid transfer protein and may const...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2014.09.017
更新日期：2014-10-13 00:00:00
abstract：:One of the biggest challenges in treating acute myeloid leukemia (AML) is relapse of aggressive disease after treatment. In this issue of Cancer Cell, Boyd et al. characterize a molecularly distinct population of chemotherapy-induced transient leukemic regenerating cells (LRCs), which can be exploited to prevent AML r...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2018.08.012
更新日期：2018-09-10 00:00:00
abstract：:MicroRNAs (miRNA) are mostly downregulated in cancer. However, the mechanism underlying this phenomenon and the precise consequence in tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation b...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2016.10.001
更新日期：2016-11-14 00:00:00
abstract：:A recent report in Science from the Varmus laboratory (Podsypanina et al., 2008) puts an interesting twist on the origins of metastatic cells, suggesting that metastases can arise in ways that are very different from those widely believed. ...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2008.09.009
更新日期：2008-10-07 00:00:00
abstract：:Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, a...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccell.2020.03.008
更新日期：2020-04-13 00:00:00
abstract：:Ampullary carcinomas represent a group of heterogeneous tumors that can be histologically divided into two subtypes with distinct pathogenic and clinical characteristics. Yachida et al. (2016) and Gingras et al. (2016) now report the genomic landscape of ampullary carcinoma, providing insights into molecular drivers w...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2016.01.011
更新日期：2016-02-08 00:00:00
abstract：:Transcription factor NF-kappaB has been implicated in cancer development due to its ability to upregulate expression of genes with potentially prooncogenic functions, such as cell cycle regulators and antiapoptotic proteins (Karin et al., 2002). A recent report by suggests that a structural motif, a death domain (DD),...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/s1535-6108(02)00213-1
更新日期：2002-12-01 00:00:00
abstract：:Expression of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) is frequently reduced in human colorectal cancer, and this correlates with poor patient prognosis. To clarify the role of p27 in gastrointestinal (GI) cancer, we measured p27 expression, as well as the effect of germline deletion of p27, in 3 differen...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/s1535-6108(02)00054-5
更新日期：2002-05-01 00:00:00
abstract：:Even in the presence of an adequate oxygen supply, many tumors metabolize the majority of the glucose they take up through glycolysis. It has been a long-held belief that this glycolytic phenotype is due to cancer-specific defects in mitochondrial oxidative phosphorylation. In this issue of Cancer Cell, Fantin et al. ...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccr.2006.05.012
更新日期：2006-06-01 00:00:00
abstract：:Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccell.2018.03.002
更新日期：2018-06-11 00:00:00
abstract：:Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now underst...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccell.2016.03.010
更新日期：2016-04-11 00:00:00
abstract：:PUMA is a pro-apoptotic Bcl-2 family protein that can act as a tumor suppressor or oncogene in different cancers. In this issue, Kim et al. show that PUMA, independent of its apoptotic function, enforces glycolytic metabolism by inhibiting the transport of pyruvate into the mitochondria, promoting hepatocellular carci...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2019.01.016
更新日期：2019-02-11 00:00:00
abstract：:To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples. Our analysis ident...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2012.10.007
更新日期：2012-11-13 00:00:00
abstract：:The role of Lyn, both a positive and a negative regulator of B and myeloid cells, in chronic lymphocytic leukemia (CLL) has not been well characterized. In this issue of Cancer Cell, Nguyen et al. demonstrated that Lyn in macrophages rather than in CLL cells is critical for the malignancy. ...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2016.09.018
更新日期：2016-10-10 00:00:00
abstract：:In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles, and have identified gene and phosphoprotein signatures associated with Lk...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2010.04.026
更新日期：2010-06-15 00:00:00
abstract：:It is widely accepted that metastasis is a late event in cancer progression. Here, however, we show that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women. Wild-type mice transplanted with single premalignant HER-2...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2007.12.003
更新日期：2008-01-01 00:00:00
abstract：:Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understandin...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2020.11.002
更新日期：2020-11-17 00:00:00
abstract：:The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions. EZH2 represses proliferation checkpoint genes and helps establish bivalent ch...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2013.04.011
更新日期：2013-05-13 00:00:00
abstract：:The BCL6 gene is a key factor necessary for formation of germinal centers and is implicated in pathogenesis of diffuse large B cell lymphoma (DLBCL). In this issue of Cancer Cell, Saito and colleagues explore regulation of BCL6 gene expression by CD40-NF-kappaB signaling pathway and show that the IRF4 transcriptional ...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccr.2007.08.012
更新日期：2007-09-01 00:00:00
abstract：:Beta-catenin and Tcf4 are the downstream effectors of the Wnt signaling cascade. In colorectal cancer, mutations in Wnt cascade genes such as APC lead to the inappropriate formation of beta-catenin/Tcf4 complexes. Earlier work has predicted that disruption of the beta-catenin/Tcf4 protein-protein interaction could rev...
journal_title：Cancer cell
pub_type： 评论,杂志文章,评审
doi：10.1016/s1535-6108(03)00339-8
更新日期：2004-01-01 00:00:00
abstract：:E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukem...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2016.06.006
更新日期：2016-07-11 00:00:00
abstract：:Receptor tyrosine kinase (RTK) recycling is of critical importance for RTK signaling and cancer, yet the process is poorly understood. In this issue, Ye et al. identify GOLM1 as a cargo adaptor that drives hepatocellular carcinoma metastasis by promoting EGFR recycling and provide insights into how this process is reg...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2016.08.014
更新日期：2016-09-12 00:00:00
abstract：:Mutations in the EGFR kinase are a cause of non-small-cell lung cancer. To understand their mechanism of activation and effects on drug binding, we studied the kinetics of the L858R and G719S mutants and determined their crystal structures with inhibitors including gefitinib, AEE788, and a staurosporine. We find that ...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2006.12.017
更新日期：2007-03-01 00:00:00
