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NEDD8 pathways in cancer, Sine Quibus Non.

Abstract：

:There are 17 known ubiquitin-like proteins (UBLs) from nine phylogenetically distinct classes (NEDD8, SUMO, ISG15, FUB1, FAT10, Atg8, Atg12, Urm1, and UFM1) that have been identified to conjugate to substrates in a manner analogous to ubiquitin. NEDD8 is one of the most studied UBLs and shares the highest amino acid similarity to ubiquitin. Here, we review the current knowledge of the NEDD8 conjugation cascade derived from functional studies in genetic model organisms, structural insights from crystallographic studies, biochemical studies identifying a growing list of NEDD8 substrates with oncogenic implications, and attempts to pharmacologically target the NEDD8 pathway in cancer.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Watson IR,Irwin MS,Ohh M

doi

10.1016/j.ccr.2011.01.002

subject

Has Abstract

pub_date

2011-02-15 00:00:00

pages

168-76

issue

2

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(11)00003-1

journal_volume

19

pub_type

杂志文章,评审

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