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Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases.

Abstract：

:Deregulation of growth factor receptor tyrosine kinases (RTKs) is linked to a large number of malignancies. This occurs through a variety of mechanisms that result in enhanced activity of the receptor. Considerable evidence now supports the idea that loss of negative regulation plays an important role in receptor deregulation. RTKs are removed from the cell surface via endocytosis and many are subsequently degraded in the lysosome. Lysosomal targeting has recently been linked with receptor ubiquitination. We review here molecular alterations that uncouple RTKs from ubiquitination and implicate loss of ubiquitination as a process that plays a significant role in the pathogenesis of cancer.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Peschard P,Park M

doi

10.1016/s1535-6108(03)00136-3

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

519-23

issue

6

eissn

1535-6108

issn

1878-3686

pii

S1535610803001363

journal_volume

3

pub_type

杂志文章

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