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p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.

Abstract：

:p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs). Although p62 was proposed to participate in the formation of benign adenomas in autophagy-deficient livers, its role in HCC initiation was not explored. Here we show that p62 is necessary and sufficient for HCC induction in mice and that its high expression in non-tumor human liver predicts rapid HCC recurrence after curative ablation. High p62 expression is needed for activation of NRF2 and mTORC1, induction of c-Myc, and protection of HCC-initiating cells from oxidative stress-induced death.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Umemura A,He F,Taniguchi K,Nakagawa H,Yamachika S,Font-Burgada J,Zhong Z,Subramaniam S,Raghunandan S,Duran A,Linares JF,Reina-Campos M,Umemura S,Valasek MA,Seki E,Yamaguchi K,Koike K,Itoh Y,Diaz-Meco MT,Moscat J,K

doi

10.1016/j.ccell.2016.04.006

subject

Has Abstract

pub_date

2016-06-13 00:00:00

pages

935-948

issue

6

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(16)30164-7

journal_volume

29

pub_type

杂志文章

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