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IRS-1: auditing the effectiveness of mTOR inhibitors.

Abstract：

:Rapamycin analogs that inhibit mTOR signaling have antitumor activity against certain lymphomas, but treatment of solid tumors has been less encouraging despite inhibition of mTOR function. Two recent papers give insight into the potential use of mTOR inhibitors. O'Reilly et al. provide evidence that poor tumor response to rapamycins is the result of relieving mTOR-mediated feedback inhibition of insulin receptor substrate 1, and activation of Akt-mediated survival. In the second paper, Kaper et al. address the impact of pathway activation on hypoxia-mediated downregulation of mTOR signaling, raising the possibility that rapalogs could selectively inhibit hypoxic cells.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Easton JB,Kurmasheva RT,Houghton PJ

doi

10.1016/j.ccr.2006.02.027

keywords:

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

153-5

issue

3

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(06)00062-6

journal_volume

9

pub_type

杂志文章,评审

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