Abstract:
:To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples. Our analysis identified a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric cases, which encodes a CBFA2T3-GLIS2 fusion protein. Expression of CBFA2T3-GLIS2 in Drosophila and murine hematopoietic cells induced bone morphogenic protein (BMP) signaling and resulted in a marked increase in the self-renewal capacity of hematopoietic progenitors. These data suggest that expression of CBFA2T3-GLIS2 directly contributes to leukemogenesis.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Gruber TA,Larson Gedman A,Zhang J,Koss CS,Marada S,Ta HQ,Chen SC,Su X,Ogden SK,Dang J,Wu G,Gupta V,Andersson AK,Pounds S,Shi L,Easton J,Barbato MI,Mulder HL,Manne J,Wang J,Rusch M,Ranade S,Ganti R,Parker M,doi
10.1016/j.ccr.2012.10.007subject
Has Abstractpub_date
2012-11-13 00:00:00pages
683-97issue
5eissn
1535-6108issn
1878-3686pii
S1535-6108(12)00438-2journal_volume
22pub_type
杂志文章相关文献
CANCER CELL文献大全abstract::Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in meta...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(04)00081-9
更新日期:2004-04-01 00:00:00
abstract::Acute promyelocytic leukemia (APL) is caused by chromosomal translocations that involve the retinoic acid receptor alpha (RAR) and several other genes to yield X-RAR fusion proteins. Unlike wild-type RARs, which require heterodimerization with the retinoid X receptor (RXR) for their function as DNA-binding transcripti...
journal_title:Cancer cell
pub_type: 评论,杂志文章,评审
doi:10.1016/j.ccr.2007.06.012
更新日期:2007-07-01 00:00:00
abstract::Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups of pHGGs. Here, we provide further insight about the dominant-negative effect of K27M mutant H3.3, leading to a global reduction of the r...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.10.006
更新日期:2013-11-11 00:00:00
abstract::Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understandin...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.11.002
更新日期:2020-11-17 00:00:00
abstract::Immune checkpoint blockade therapies fail to induce responses in the majority of cancer patients, so how to increase the objective response rate becomes an urgent challenge. Here, we demonstrate that sufficient T cell infiltration in tumor tissues is a prerequisite for response to PD-L1 blockade. Targeting tumors with...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.02.004
更新日期:2016-03-14 00:00:00
abstract::PUMA is a pro-apoptotic Bcl-2 family protein that can act as a tumor suppressor or oncogene in different cancers. In this issue, Kim et al. show that PUMA, independent of its apoptotic function, enforces glycolytic metabolism by inhibiting the transport of pyruvate into the mitochondria, promoting hepatocellular carci...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2019.01.016
更新日期:2019-02-11 00:00:00
abstract::Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloi...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.08.019
更新日期:2011-09-13 00:00:00
abstract::Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitant...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.01.027
更新日期:2009-03-03 00:00:00
abstract::Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) potential. KDM1A acts at genomic loci bound by MLL-AF9 to sustain expression of the associated oncogenic program, thus preventing differentiation and a...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.03.014
更新日期:2012-04-17 00:00:00
abstract::Recent studies have identified genes and core pathways that are altered in human glioblastoma. However, the mechanisms by which alterations of these glioblastoma genes singly and cooperatively transform brain cells remain poorly understood. Further, the cell of origin of glioblastoma is largely elusive. By targeting a...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.04.001
更新日期:2009-06-02 00:00:00
abstract::In this issue of Cancer Cell, Volk et al. report that overexpression of CHAF1B displaces myeloid transcription factors from chromatin, and deletion of CHAF1B promotes differentiation of leukemia cells and suppresses leukemogenesis in a murine model, revealing a causal role of and an unexpected mechanism for CHAF1B ove...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2018.10.011
更新日期:2018-11-12 00:00:00
abstract::Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.10.010
更新日期:2016-12-12 00:00:00
abstract::In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction nee...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2019.06.004
更新日期:2019-07-08 00:00:00
abstract::Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now underst...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2016.03.010
更新日期:2016-04-11 00:00:00
abstract::A recent report in Science from the Varmus laboratory (Podsypanina et al., 2008) puts an interesting twist on the origins of metastatic cells, suggesting that metastases can arise in ways that are very different from those widely believed. ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2008.09.009
更新日期:2008-10-07 00:00:00
abstract::Whether metastasis-specific genetic alterations exist remains controversial. The study by Yates et al. in this issue of Cancer Cell provides evidence that metastases emerge late during primary breast cancer progression and that additional driver mutations are often acquired, posing both challenges and opportunities fo...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.07.011
更新日期:2017-08-14 00:00:00
abstract::Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2007.05.004
更新日期:2007-06-01 00:00:00
abstract::In this issue of Cancer Cell, demonstrate a novel mechanism for the oncogenic activity of MLL chimeric proteins. By providing coiled-coil or other dimerization domains, the cytoplasmic partners of MLL fusion proteins donate a platform for MLL homodimerization, allowing recruitment of accessory factors needed to activa...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/s1535-6108(03)00192-2
更新日期:2003-08-01 00:00:00
abstract::It is believed that Mdm2 suppresses p53 in two ways: transcriptional inhibition by direct binding, and degradation via its E3 ligase activity. To study these functions physiologically, we generated mice bearing a single-residue substitution (C462A) abolishing the E3 function without affecting p53 binding. Unexpectedly...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2007.09.007
更新日期:2007-10-01 00:00:00
abstract::Activating mutations in GNAQ/GNA11, encoding Gαq G proteins, are initiating oncogenic events in uveal melanoma (UM). However, there are no effective therapies for UM. Using an integrated bioinformatics pipeline, we found that PTK2, encoding focal adhesion kinase (FAK), represents a candidate synthetic lethal gene with...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2019.01.009
更新日期:2019-03-18 00:00:00
abstract::Overexpression of Bcl-xL, loss of p19 ARF, and loss of p53 all accelerate Myc oncogenesis. All three lesions are implicated in suppressing Myc-induced apoptosis, suggesting that this is a common mechanism by which they synergize with Myc. However, using an acutely switchable model of Myc-induced tumorigenesis, we demo...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.06.017
更新日期:2006-08-01 00:00:00
abstract::Controversy over the role of antioxidants in cancer has persisted for decades. Here, we demonstrate that synthesis of the antioxidant glutathione (GSH), driven by GCLM, is required for cancer initiation. Genetic loss of Gclm prevents a tumor's ability to drive malignant transformation. Intriguingly, these findings can...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.11.019
更新日期:2015-02-09 00:00:00
abstract::Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX loci as hematopoietic cells mature, thus coinciding with a decrease in HOX gene expression. We show that H3K79 methyltrans...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.10.009
更新日期:2014-12-08 00:00:00
abstract::PPARgamma is a member of the nuclear receptor family for which agonist ligands have antigrowth effects. However, clinical studies using PPARgamma ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARgamma activation with chemotherapeutic agents in current use for specifi...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2007.02.025
更新日期:2007-05-01 00:00:00
abstract::The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-dama...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2008.04.010
更新日期:2008-05-01 00:00:00
abstract::Therapies that target estrogen signaling have transformed the treatment of breast cancer. However, the effectiveness of these agents is limited by the development of resistance. Here, an RNAi screen was used to identify modifiers of tamoxifen sensitivity. We demonstrate that CDK10 is an important determinant of resist...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2008.01.001
更新日期:2008-02-01 00:00:00
abstract::The receptor tyrosine kinase HER2 enhances tumor metastasis; however, its role in homing to metastatic organs is poorly understood. The chemokine receptor CXCR4 has recently been shown to mediate the movement of malignant cancer cells to specific organs. Here, we show that HER2 enhances the expression of CXCR4, which ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2004.09.027
更新日期:2004-11-01 00:00:00
abstract::Immunotherapy has changed the landscape of cancer treatment. Checkpoint blockade therapies unleash breaks in the immune system and induce long-lasting responses. However, a significant number of patients do not respond (innate resistance), and a subset progress after responding (acquired resistance). A better understa...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.05.010
更新日期:2017-06-12 00:00:00
abstract::To investigate the role of signaling by the small GTPase Ral, we have generated mice deficient for RalGDS, a guanine nucleotide exchange factor that activates Ral. We show that RalGDS is dispensable for mouse development but plays a substantial role in Ras-induced oncogenesis. Lack of RalGDS results in reduced tumor i...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.01.029
更新日期:2005-03-01 00:00:00
abstract::Monosomy 7 and interstitial deletion of 7q (-7/7q-) are well-recognized nonrandom chromosomal abnormalities frequently found among patients with myelodysplastic syndromes (MDSs) and myeloid leukemias. We previously identified candidate myeloid tumor suppressor genes (SAMD9, SAMD9-like = SAMD9L, and Miki) in the 7q21.3...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.08.011
更新日期:2013-09-09 00:00:00