Abstract:
:Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a few targets have been developed for clinical therapeutics. By thorough SAGE analysis of mouse endothelial cells isolated from various normal resting tissues, regenerating liver, and liver-metastasized tumor, Seaman and colleagues in this issue of Cancer Cell have demonstrated organ-specific endothelial markers, physiological angiogenesis endothelial markers, and tumor endothelial markers and revealed striking differences between physiological and pathological angiogenesis.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Li JL,Harris ALdoi
10.1016/j.ccr.2007.05.004subject
Has Abstractpub_date
2007-06-01 00:00:00pages
478-81issue
6eissn
1535-6108issn
1878-3686pii
S1535-6108(07)00148-1journal_volume
11pub_type
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