The potential of new tumor endothelium-specific markers for the development of antivascular therapy.

Abstract:

:Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a few targets have been developed for clinical therapeutics. By thorough SAGE analysis of mouse endothelial cells isolated from various normal resting tissues, regenerating liver, and liver-metastasized tumor, Seaman and colleagues in this issue of Cancer Cell have demonstrated organ-specific endothelial markers, physiological angiogenesis endothelial markers, and tumor endothelial markers and revealed striking differences between physiological and pathological angiogenesis.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Li JL,Harris AL

doi

10.1016/j.ccr.2007.05.004

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

478-81

issue

6

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(07)00148-1

journal_volume

11

pub_type

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