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Turning on a dimer: new insights into MLL chimeras.

Abstract：

:In this issue of Cancer Cell, demonstrate a novel mechanism for the oncogenic activity of MLL chimeric proteins. By providing coiled-coil or other dimerization domains, the cytoplasmic partners of MLL fusion proteins donate a platform for MLL homodimerization, allowing recruitment of accessory factors needed to activate the critical downstream targets, including selected subsets of the major HOX genes.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Hsu K,Look AT

doi

10.1016/s1535-6108(03)00192-2

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

81-3

issue

2

eissn

1535-6108

issn

1878-3686

pii

S1535610803001922

journal_volume

4

pub_type

评论,杂志文章

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