Abstract：
:A definitive knockout reported in this issue of Cancer Cell by Sicinska et al. reveals an unsuspected role for cyclin D3 in normal T cell development and suggests new therapeutic possibilities in precursor T cell leukemia.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Weng AP,Aster JCdoi
10.1016/s1535-6108(03)00305-2keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
417-8issue
6eissn
1535-6108issn
1878-3686pii
S1535610803003052journal_volume
4pub_type
评论,杂志文章,评审相关文献
CANCER CELL文献大全abstract：:Homeobox domain-containing transcription factors are important regulators of hematopoiesis. Here, we report that increased levels of nonclustered H2.0-like homeobox (HLX) lead to loss of functional hematopoietic stem cells and formation of aberrant progenitors with unlimited serial clonogenicity and blocked differenti...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2012.06.027
更新日期：2012-08-14 00:00:00
abstract：:Human T cell leukemias can arise from oncogenes activated by specific chromosomal translocations involving the T cell receptor genes. Here we show that five different T cell oncogenes (HOX11, TAL1, LYL1, LMO1, and LMO2) are often aberrantly expressed in the absence of chromosomal abnormalities. Using oligonucleotide m...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/s1535-6108(02)00018-1
更新日期：2002-02-01 00:00:00
abstract：:T cell engineering is a powerful means to rapidly generate anti-tumor T cells. The costimulatory properties of second-generation chimeric antigen receptors (CARs) determine the overall potency of adoptively transferred T cells. Using an in vivo "stress test" to challenge CD19-targeted T cells, we studied the functiona...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2015.09.004
更新日期：2015-10-12 00:00:00
abstract：:EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but signals constitutively. Deducing how EGFRvIII causes transformation has been difficult because of autocrine and paracrine loops triggered by EGFRvIII alone or in heterodimers with wild-type EGFR...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2013.09.004
更新日期：2013-10-14 00:00:00
abstract：:Metastases arising from tumors have the proclivity to colonize specific organs, suggesting that they must rewire their biology to meet the demands of the organ colonized, thus altering their primary properties. Each metastatic site presents distinct metabolic challenges to a colonizing cancer cell, ranging from fuel a...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccell.2018.02.001
更新日期：2018-03-12 00:00:00
abstract：:Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccr.2013.04.004
更新日期：2013-04-15 00:00:00
abstract：:PPARgamma is a member of the nuclear receptor family for which agonist ligands have antigrowth effects. However, clinical studies using PPARgamma ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARgamma activation with chemotherapeutic agents in current use for specifi...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2007.02.025
更新日期：2007-05-01 00:00:00
abstract：:Identifying contexts in which cancer cells become addicted to specific nutrients is critical for developing targeted metabolic therapies. In this issue of Cancer Cell, Momcilovic et al. report that suppressed glycolysis following mTOR inhibition is countered by adaptive glutamine catabolism in lung squamous cell carci...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2018.04.009
更新日期：2018-05-14 00:00:00
abstract：:Loss of p53 is considered to allow progression of colorectal tumors from the adenoma to the carcinoma stage. Using mice with an intestinal epithelial cell (IEC)-specific p53 deletion, we demonstrate that loss of p53 alone is insufficient to initiate intestinal tumorigenesis but markedly enhances carcinogen-induced tum...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2012.11.014
更新日期：2013-01-14 00:00:00
abstract：:In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. Pharmacological inhibition of GATA2-mediated pathways with bortezomib and fasudil results in dramatic tumor inhibition. These observations...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccr.2012.04.032
更新日期：2012-05-15 00:00:00
abstract：:Abnormal activation of the epidermal growth factor receptor (EGFR) and its homolog HER2 (Neu/ErbB2) has been associated with many human cancers, and monoclonal antibodies targeting EGFR and HER2 are effective anticancer therapies. Structural studies of these receptors and antibodies have revealed much about how they f...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccr.2008.03.010
更新日期：2008-04-01 00:00:00
abstract：:Heterozygous somatic mutations in the spliceosome gene U2AF1 occur in ∼ 11% of patients with myelodysplastic syndromes (MDS), the most common adult myeloid malignancy. It is unclear how these mutations contribute to disease. We examined in vivo hematopoietic consequences of the most common U2AF1 mutation using a doxyc...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2015.04.008
更新日期：2015-05-11 00:00:00
abstract：:Specific phosphoinositide lipids promote cell growth and cancer. In this issue of Cancer Cell, Fayngerts and colleagues demonstrate that the TIPE3 protein enhances PtdIns(4,5)P2 and PtdIns(3,4,5)P3, is overexpressed in certain cancers, and promotes tumorigenesis. TIPE3 can act as a lipid transfer protein and may const...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2014.09.017
更新日期：2014-10-13 00:00:00
abstract：:Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPKCs have pleiotropic context-dependent functions that can translate into ...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccell.2019.07.010
更新日期：2019-09-16 00:00:00
abstract：:Adaptive chemoresistance and consequent tumor recurrence present major obstacles to the improvement of the prognosis and quality-of-life of patients with advanced-stage ovarian cancer. In this issue of Cancer Cell, Yu and colleagues describe the critical role of spleen tyrosine kinase (SYK) in paclitaxel resistance by...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2015.06.008
更新日期：2015-07-13 00:00:00
abstract：:The COVID-19 pandemic is profoundly changing cancer researchers and cancer research. Leaders from different fields and at different career stages share their perspectives. ...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2020.10.007
更新日期：2020-11-09 00:00:00
abstract：:Neuropilin-1 (NRP1) guides the development of the nervous and vascular systems. Binding to either semaphorins or VEGF, NRP1 acts with plexins to regulate neuronal guidance, or with VEGFR2 to mediate vascular development. We have generated two monoclonal antibodies that bind to the Sema- and VEGF-binding domains of NRP...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2006.10.018
更新日期：2007-01-01 00:00:00
abstract：:Therapies that target estrogen signaling have transformed the treatment of breast cancer. However, the effectiveness of these agents is limited by the development of resistance. Here, an RNAi screen was used to identify modifiers of tamoxifen sensitivity. We demonstrate that CDK10 is an important determinant of resist...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2008.01.001
更新日期：2008-02-01 00:00:00
abstract：:Breast cancer is a heterogeneous disease and can be classified based on gene expression profiles that reflect distinct epithelial subtypes. We identify prostate-derived ETS factor (PDEF) as a mediator of mammary luminal epithelial lineage-specific gene expression and as a factor required for tumorigenesis in a subset ...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2013.04.026
更新日期：2013-06-10 00:00:00
abstract：:To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-wide screen in yeast identified mitochondrial translation inhibition as the mechanism of tigecycline-mediated lethality. Tigecycline selective...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2011.10.015
更新日期：2011-11-15 00:00:00
abstract：:We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas. We demonstrated that cancer subtypes and ancestry-related technical artifacts are important confounders that have been insufficiently accounted for....
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2020.04.012
更新日期：2020-05-11 00:00:00
abstract：:Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic steatohepatitis (NASH), a common cause of HCC. URI-induced DNA damage in hepatocytes triggers inflammation via...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2016.05.020
更新日期：2016-07-11 00:00:00
abstract：:Although signaling from phosphatidylinositol 3-kinase (PI3K) and AKT to mechanistic target of rapamycin (mTOR) is prominently dysregulated in high-grade glial brain tumors, blockade of PI3K or AKT minimally affects downstream mTOR activity in glioma. Allosteric mTOR inhibitors, such as rapamycin, incompletely block mT...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2017.01.014
更新日期：2017-03-13 00:00:00
abstract：:It is widely accepted that metastasis is a late event in cancer progression. Here, however, we show that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women. Wild-type mice transplanted with single premalignant HER-2...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2007.12.003
更新日期：2008-01-01 00:00:00
abstract：:In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction nee...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2019.06.004
更新日期：2019-07-08 00:00:00
abstract：:Amino acid (AA) is a potent mitogen that controls growth and metabolism. Here we describe the identification of Rab1 as a conserved regulator of AA signaling to mTORC1. AA stimulates Rab1A GTP binding and interaction with mTORC1 and Rheb-mTORC1 interaction in the Golgi. Rab1A overexpression promotes mTORC1 signaling a...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2014.09.008
更新日期：2014-11-10 00:00:00
abstract：:Recent genomic analyses of pediatric glioblastoma, a poorly understood tumor with dismal outcome, have identified mutations in histone H3 variants that affect critical amino acids in the tail. The findings extend discoveries of chromatin regulator inactivation and gain-of-function mutations by documenting alteration o...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2012.03.001
更新日期：2012-03-20 00:00:00
abstract：:The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent chromatin domains at critical germinal center (GC) B cell promoters. Herein we show that the actions of EZH2 in driving GC formation and lymphoma precursor lesions require site-specific bind...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2016.07.006
更新日期：2016-08-08 00:00:00
abstract：:CAR-engineered T cell immunotherapy has proven transformative in selected hematological malignancies. However, solid tumors largely remain impervious to these approaches. In addressing this challenge, Srivastava et al. in this issue demonstrate that oxaliplatin-based lymphodepleting chemotherapy promotes enhanced CAR ...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2020.12.019
更新日期：2020-12-30 00:00:00
abstract：:The telomere-stabilizing enzyme telomerase is induced in tumors and functionally associated with unlimited replicative potential. To further explore its necessity, transgenic mice expressing SV40 or HPV16 oncogenes, which elicit carcinomas in pancreas and skin, respectively, were rendered telomerase-deficient. Absence...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2004.08.032
更新日期：2004-10-01 00:00:00
