Abstract:
:In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. Pharmacological inhibition of GATA2-mediated pathways with bortezomib and fasudil results in dramatic tumor inhibition. These observations unveil new armamentaria to fight this deadly disease.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Barbacid Mdoi
10.1016/j.ccr.2012.04.032subject
Has Abstractpub_date
2012-05-15 00:00:00pages
598-600issue
5eissn
1535-6108issn
1878-3686pii
S1535-6108(12)00172-9journal_volume
21pub_type
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