Abstract：
:Cancer-associated chromosomal translocations create chimeric oncoproteins that contribute to aberrant growth by dominant or dominant negative mechanisms. Interestingly, genes such as MLL, RARA, and EWS are fused to multiple partners. This molecular promiscuity can provide important functional information, as specific translocations may be associated with discrete clinical and molecular features. In this issue of Cancer Cell, use a murine retroviral transduction/transplantation system to analyze two FGFR1 fusions found in hematologic malignancies. Their results show that these chromosomal rearrangements play a central role in pathogenesis, underscore the role of partner genes in modulating disease phenotypes, and uncover potential therapeutic targets.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Braun BS,Shannon Kdoi
10.1016/s1535-6108(04)00060-1keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
203-4issue
3eissn
1535-6108issn
1878-3686pii
S1535610804000601journal_volume
5pub_type
杂志文章,评审相关文献
CANCER CELL文献大全abstract：:Breast cancer is a heterogeneous disease and can be classified based on gene expression profiles that reflect distinct epithelial subtypes. We identify prostate-derived ETS factor (PDEF) as a mediator of mammary luminal epithelial lineage-specific gene expression and as a factor required for tumorigenesis in a subset ...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2013.04.026
更新日期：2013-06-10 00:00:00
abstract：:8p11 myeloproliferative syndrome (EMS) is a hematopoietic stem cell disorder characterized by myeloid hyperplasia and non-Hodgkin's lymphoma with chromosomal translocations fusing several genes, most commonly ZNF198, to fibroblast growth factor receptor-1 (FGFR1). However, patients with BCR-FGFR1 fusion present with t...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/s1535-6108(04)00053-4
更新日期：2004-03-01 00:00:00
abstract：:The life history of cancer cells encompasses a series of genetic missteps in which normal cells are progressively transformed into tumor cells that invade surrounding tissues and become malignant. Most prominent among the regulators disrupted in cancer cells are two tumor suppressors, the retinoblastoma protein (RB) a...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/s1535-6108(02)00102-2
更新日期：2002-08-01 00:00:00
abstract：:Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, a...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccell.2020.03.008
更新日期：2020-04-13 00:00:00
abstract：:Perturbation biology is a powerful approach to modeling quantitative cellular behaviors and understanding detailed disease mechanisms. However, large-scale protein response resources of cancer cell lines to perturbations are not available, resulting in a critical knowledge gap. Here we generated and compiled perturbed...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2020.10.008
更新日期：2020-12-14 00:00:00
abstract：:The cell culture environment (substrate, atmosphere, and medium) can have a significant influence on the characteristics of cells that propagate from clinical samples. In this issue of Cancer Cell, Ince and colleagues report improved conditions for the culture of primary human breast epithelial cells. They demonstrate...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccr.2007.07.012
更新日期：2007-08-01 00:00:00
abstract：:Agonistic antibodies specific for members of the tumor necrosis factor receptor protein family hold great promise for immunotherapy of cancer. In this issue of Cancer Cell, White and colleagues provide evidence that the human IgG2 subclass may represent a superior backbone for the use of these antibodies in human ther...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2014.12.010
更新日期：2015-01-12 00:00:00
abstract：:Oncoproteins and tumor suppressors antagonistically converge on critical nodes governing neoplastic growth, invasion, and metastasis. We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2014.06.026
更新日期：2014-08-11 00:00:00
abstract：:Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from i...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2020.08.012
更新日期：2020-09-14 00:00:00
abstract：:To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-wide screen in yeast identified mitochondrial translation inhibition as the mechanism of tigecycline-mediated lethality. Tigecycline selective...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2011.10.015
更新日期：2011-11-15 00:00:00
abstract：:The childhood brain tumor, medulloblastoma, includes four subtypes with very different prognoses. Here, we show that paracrine signals driven by mutant β-catenin in WNT-medulloblastoma, an essentially curable form of the disease, induce an aberrant fenestrated vasculature that permits the accumulation of high levels o...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2016.03.002
更新日期：2016-04-11 00:00:00
abstract：:Obesity is a leading risk factor for cancer. However, understanding the crosstalk between adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in the field. Here we used a prostate cancer (PCa) mouse model in which the signaling adaptor p62/Sqstm1 is selectively inactivated in adi...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2018.03.001
更新日期：2018-04-09 00:00:00
abstract：:Rapamycin analogs that inhibit mTOR signaling have antitumor activity against certain lymphomas, but treatment of solid tumors has been less encouraging despite inhibition of mTOR function. Two recent papers give insight into the potential use of mTOR inhibitors. O'Reilly et al. provide evidence that poor tumor respon...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccr.2006.02.027
更新日期：2006-03-01 00:00:00
abstract：:The mechanisms through which tumor antigen-specific T cells are elicited in natural or chemotherapy-induced immunosurveillance have been elusive. In this issue of Cancer Cell, two papers by Broz and colleagues and Ruffell and colleagues delineate an important role for a specific dendritic cell subset characterized by ...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2014.10.008
更新日期：2014-11-10 00:00:00
abstract：:The telomere-stabilizing enzyme telomerase is induced in tumors and functionally associated with unlimited replicative potential. To further explore its necessity, transgenic mice expressing SV40 or HPV16 oncogenes, which elicit carcinomas in pancreas and skin, respectively, were rendered telomerase-deficient. Absence...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2004.08.032
更新日期：2004-10-01 00:00:00
abstract：:PPARgamma is a member of the nuclear receptor family for which agonist ligands have antigrowth effects. However, clinical studies using PPARgamma ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARgamma activation with chemotherapeutic agents in current use for specifi...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2007.02.025
更新日期：2007-05-01 00:00:00
abstract：:We report that mouse LSL-KrasG12D;Trp53fl/fl (KP)-mediated lung adenocarcinoma (LADC) tumorigenesis can proceed through both PKCι-dependent and PKCι-independent pathways. The predominant pathway involves PKCι-dependent transformation of bronchoalveolar stem cells (BASCs). However, KP mice harboring conditional knock o...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2019.07.002
更新日期：2019-08-12 00:00:00
abstract：:Acute promyelocytic leukemia (APL) is caused by chromosomal translocations that involve the retinoic acid receptor alpha (RAR) and several other genes to yield X-RAR fusion proteins. Unlike wild-type RARs, which require heterodimerization with the retinoid X receptor (RXR) for their function as DNA-binding transcripti...
journal_title：Cancer cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.ccr.2007.06.012
更新日期：2007-07-01 00:00:00
abstract：:Although signaling from phosphatidylinositol 3-kinase (PI3K) and AKT to mechanistic target of rapamycin (mTOR) is prominently dysregulated in high-grade glial brain tumors, blockade of PI3K or AKT minimally affects downstream mTOR activity in glioma. Allosteric mTOR inhibitors, such as rapamycin, incompletely block mT...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2017.01.014
更新日期：2017-03-13 00:00:00
abstract：:Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are particularly prevalent, occurring in 20% of all human cancers. As these are typicall...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccr.2014.07.018
更新日期：2014-09-08 00:00:00
abstract：:Receptor tyrosine kinase (RTK) recycling is of critical importance for RTK signaling and cancer, yet the process is poorly understood. In this issue, Ye et al. identify GOLM1 as a cargo adaptor that drives hepatocellular carcinoma metastasis by promoting EGFR recycling and provide insights into how this process is reg...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2016.08.014
更新日期：2016-09-12 00:00:00
abstract：:A definitive knockout reported in this issue of Cancer Cell by Sicinska et al. reveals an unsuspected role for cyclin D3 in normal T cell development and suggests new therapeutic possibilities in precursor T cell leukemia. ...
journal_title：Cancer cell
pub_type： 评论,杂志文章,评审
doi：10.1016/s1535-6108(03)00305-2
更新日期：2003-12-01 00:00:00
abstract：:The SH2-containing tyrosine phosphatase Shp2 (PTPN11) is required for growth factor and cytokine signaling. Germline Shp2 mutations cause Noonan Syndrome (NS), which is associated with increased risk of juvenile myelomonocytic leukemia (JMML). Somatic Shp2 mutations occur in sporadic JMML and other leukemias. We found...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2005.01.010
更新日期：2005-02-01 00:00:00
abstract：:Tumors constitute highly suppressive microenvironments in which infiltrating T cells are "exhausted" by inhibitory receptors such as PD-1. Here we identify TIGIT as a coinhibitory receptor that critically limits antitumor and other CD8(+) T cell-dependent chronic immune responses. TIGIT is highly expressed on human an...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2014.10.018
更新日期：2014-12-08 00:00:00
abstract：:Adler et al., in a paper appearing in Nature Genetics, exploited the intersect of genetic information from expression profiles with that from array comparative genomic hybridization in human breast cancers to identify genes that may induce the transcription of the prognostic "wound response" expression signature. The ...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccr.2006.03.026
更新日期：2006-04-01 00:00:00
abstract：:E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukem...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2016.06.006
更新日期：2016-07-11 00:00:00
abstract：:Ras proteins play a major role in human cancers but have not yielded to therapeutic attack. Ras-driven cancers are among the most difficult to treat and often excluded from therapies. The Ras proteins have been termed "undruggable," based on failures from an era in which understanding of signaling transduction, feedba...
journal_title：Cancer cell
pub_type： 杂志文章,评审
doi：10.1016/j.ccr.2014.02.017
更新日期：2014-03-17 00:00:00
abstract：:In this issue of Cancer Cell, Kumar et al. describe how CSF1R blockade induces not only an expected deprivation of tumor-associated macrophages, but also an accumulation of tumor-infiltrating polymorphonuclear mononuclear cells caused by Cxcl-1 released from cancer-associated fibroblasts. ...
journal_title：Cancer cell
pub_type： 评论,杂志文章
doi：10.1016/j.ccell.2017.10.012
更新日期：2017-11-13 00:00:00
abstract：:Targeted protein degradation is an emerging technology for drug development. An article published in Nature reported a novel mechanism of targeted protein degradation triggered by small-molecule-induced polymerization of the oncogenic transcription factor BCL6. ...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccell.2020.12.020
更新日期：2021-01-11 00:00:00
abstract：:The proapoptotic death receptor DR5 has been studied extensively in cancer cells, but its action in the tumor microenvironment is not well defined. Here, we uncover a role for DR5 signaling in tumor endothelial cells (ECs). We detected DR5 expression in ECs within tumors but not normal tissues. Treatment of tumor-bear...
journal_title：Cancer cell
pub_type： 杂志文章
doi：10.1016/j.ccr.2012.05.014
更新日期：2012-07-10 00:00:00
