Abstract:
:Constitutive activation of NF-κB signaling can promote oncogenesis, providing a rationale for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes & Development provide evidence that, in contexts where prosurvival signals derive from other oncogenes, NF-κB activity instead enhances sensitivity to cytotoxic chemotherapy, thereby exerting a tumor-suppressor function.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Klein U,Ghosh Sdoi
10.1016/j.ccr.2011.10.026subject
Has Abstractpub_date
2011-11-15 00:00:00pages
556-8issue
5eissn
1535-6108issn
1878-3686pii
S1535-6108(11)00402-8journal_volume
20pub_type
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