Abstract:
:A specific association with mixed lineage leukemias suggests that MLL oncoproteins may selectively target early multipotent hematopoietic progenitors or stem cells. We demonstrate here that a representative MLL fusion protein, MLL-GAS7, impairs the differentiation and enhances the in vitro growth of murine hematopoietic cells with multipotent features. The multilineage differentiation potential of these cells was suggested by their immuno-phenotypes and transcriptional programs and confirmed by their ability to induce three pathologically distinct leukemias in mice, including an acute biphenotypic leukemia (ABL) that recapitulates the distinctive hallmark features of many MLL-associated leukemias in humans. This experimental modeling of ABL in mice highlights its origin from multipotential progenitors that arrest at a bipotential stage specifically targeted or induced by MLL oncogenes.
journal_name
Cancer Celljournal_title
Cancer cellauthors
So CW,Karsunky H,Passegué E,Cozzio A,Weissman IL,Cleary MLdoi
10.1016/s1535-6108(03)00019-9keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
161-71issue
2eissn
1535-6108issn
1878-3686pii
S1535610803000199journal_volume
3pub_type
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