Abstract:
:Small numbers of proangiogenic bone marrow-derived cells (BMDCs) can play pivotal roles in tumor progression. In this issue of Cancer Cell, two papers, utilizing different tumor angiogenesis models, both find that activated MMP-9 delivered by BMDCs modulates neovessel remodeling, thereby promoting tumor growth. The changes in microvascular anatomy induced by MMP-9-expressing BMDCs are strikingly different between the preirradiated tumor vascular bed model employed by Ahn and Brown and the invasive glioblastoma model utilized by Du et al., likely mirroring the complexity of the real tumor microenvironment and the intricacy of roles of different BMDC populations in mediating tumor neoangiogenesis.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Seandel M,Butler J,Lyden D,Rafii Sdoi
10.1016/j.ccr.2008.02.016subject
Has Abstractpub_date
2008-03-01 00:00:00pages
181-3issue
3eissn
1535-6108issn
1878-3686pii
S1535-6108(08)00052-4journal_volume
13pub_type
评论,杂志文章相关文献
CANCER CELL文献大全abstract::From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial protease that has structural similarity to the cytoplasmic proteosome is increased in leukemic cells from approximately half of all patients ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2015.05.004
更新日期:2015-06-08 00:00:00
abstract::Tumors constitute highly suppressive microenvironments in which infiltrating T cells are "exhausted" by inhibitory receptors such as PD-1. Here we identify TIGIT as a coinhibitory receptor that critically limits antitumor and other CD8(+) T cell-dependent chronic immune responses. TIGIT is highly expressed on human an...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.10.018
更新日期:2014-12-08 00:00:00
abstract::Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms underlying NASH and NASH-induced HCC are largely unknown. We developed a mouse model recapitulating key features of human metabolic syndrome, NASH, ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.09.003
更新日期:2014-10-13 00:00:00
abstract::MYC is an oncogenic driver that regulates transcriptional activation and repression. Surprisingly, mechanisms by which MYC promotes malignant transformation remain unclear. We demonstrate that MYC interacts with the G9a H3K9-methyltransferase complex to control transcriptional repression. Inhibiting G9a hinders MYC ch...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.09.001
更新日期:2018-10-08 00:00:00
abstract::In this issue of Cancer Cell, Park et al. demonstrate that anti-erbB2 antibody primes adaptive immunity for increased tumor clearance and suggest that chemotherapy may in fact interfere with this process. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2010.07.009
更新日期:2010-08-09 00:00:00
abstract::Breast cancer is a heterogeneous disease and can be classified based on gene expression profiles that reflect distinct epithelial subtypes. We identify prostate-derived ETS factor (PDEF) as a mediator of mammary luminal epithelial lineage-specific gene expression and as a factor required for tumorigenesis in a subset ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.04.026
更新日期:2013-06-10 00:00:00
abstract::The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with e...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.08.008
更新日期:2006-09-01 00:00:00
abstract::Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of hereditary (VHL Disease-associated) and sporadic clear cell carcinoma of the kidney. The VHL gene product, pVHL, targets the heterodimeric transcription factor HIF for polyubiquitination, and restoration of pVHL function in VHL...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(02)00043-0
更新日期:2002-04-01 00:00:00
abstract::The erythroleukemia developed by spi-1/PU.1 transgenic mice is a multistage process characterized by an early arrest of the proerythroblast differentiation followed later on by malignant transformation. Herein, we report the presence of acquired mutations in the SCF receptor gene (Kit) in 86% of tumors isolated during...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.11.009
更新日期:2005-12-01 00:00:00
abstract::The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increased ROS in PDAC cel...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2019.12.012
更新日期:2020-02-10 00:00:00
abstract::EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but signals constitutively. Deducing how EGFRvIII causes transformation has been difficult because of autocrine and paracrine loops triggered by EGFRvIII alone or in heterodimers with wild-type EGFR...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.09.004
更新日期:2013-10-14 00:00:00
abstract::Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy are needed for this large patient group. We defined two major genomic subtypes of primary stage Ta tumors. One of these was characterized by...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.08.005
更新日期:2017-11-13 00:00:00
abstract::Cancer cells reprogram their metabolism using different strategies to meet energy and anabolic demands to maintain growth and survival. Understanding the molecular and genetic determinants of these metabolic programs is critical to successfully exploit them for therapy. Here, we report that the oncogenic melanocyte li...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.11.020
更新日期:2013-03-18 00:00:00
abstract::Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for react...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.08.020
更新日期:2012-09-11 00:00:00
abstract::The molecular mechanisms regulating leukemia-initiating cell (LIC) function are of important clinical significance. We use chronic myelogenous leukemia (CML) as a model of LIC-dependent malignancy and identify the interaction between the ubiquitin ligase Fbw7 and its substrate c-Myc as a regulator of LIC homeostasis. ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.01.025
更新日期:2013-03-18 00:00:00
abstract::PPARgamma is a member of the nuclear receptor family for which agonist ligands have antigrowth effects. However, clinical studies using PPARgamma ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARgamma activation with chemotherapeutic agents in current use for specifi...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2007.02.025
更新日期:2007-05-01 00:00:00
abstract::Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) potential. KDM1A acts at genomic loci bound by MLL-AF9 to sustain expression of the associated oncogenic program, thus preventing differentiation and a...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.03.014
更新日期:2012-04-17 00:00:00
abstract::The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways. Here, we report that conditional ablation of TAK1 in liver parenchymal cells (hepatocytes and cholangiocytes) causes hepatoc...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2010.03.021
更新日期:2010-05-18 00:00:00
abstract::Tumorigenesis is often associated with an unbalanced protein homeostasis (proteostasis) network, which sensitizes cancer cells to drugs targeting protein quality control (PQC) regulators. In this issue of Cancer Cell, Anderson and colleagues investigated the anti-cancer activity of a new class of inhibitor against a m...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2015.10.006
更新日期:2015-11-09 00:00:00
abstract::Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation of NE prostate tumors in the TRAMP mouse model was suppressed in mice lacking the ubiquitin ligase Siah2, which regulates HIF-1alpha availability. Cooperation be...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2010.05.024
更新日期:2010-07-13 00:00:00
abstract::The Twist1 transcription factor is known to promote tumor metastasis and induce Epithelial-Mesenchymal Transition (EMT). Here, we report that Twist1 is capable of promoting the formation of invadopodia, specialized membrane protrusions for extracellular matrix degradation. Twist1 induces PDGFRα expression, which in tu...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.01.036
更新日期:2011-03-08 00:00:00
abstract::Recent structural studies of epidermal growth factor receptor (EGFR) family extracellular regions have identified an unexpected mechanism for ligand-induced receptor dimerization that has important implications for activation and inhibition of these receptors. Here we describe the 2.8 angstroms resolution X-ray crysta...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.03.003
更新日期:2005-04-01 00:00:00
abstract::When the COVID-19 pandemic began, formal frameworks to collect data about affected patients were lacking. The COVID-19 and Cancer Consortium (CCC19) was formed to collect granular data on patients with cancer and COVID-19 at scale and as rapidly as possible. CCC19 has grown from five initial institutions to 125 instit...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.10.022
更新日期:2020-12-14 00:00:00
abstract::Here, we show that tumor ADORA1 deletion suppresses cell growth in human melanoma cell lines in vitro and tumor development in vivo in immune-deficient xenografts. However, this deletion induces the upregulation of PD-L1 levels, which inactivates cocultured T cells in vitro, compromises anti-tumor immunity in vivo, an...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.02.006
更新日期:2020-03-16 00:00:00
abstract::MDM2 has been characterized as a protein that binds to and facilitates degradation of the tumor suppressor p53. Interestingly, more than 40 different splice variants of MDM2 transcripts have been identified both in tumors and normal tissues, and the majority of these variants do not contain sequence encoding the p53 b...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(02)00091-0
更新日期:2002-07-01 00:00:00
abstract::A definitive knockout reported in this issue of Cancer Cell by Sicinska et al. reveals an unsuspected role for cyclin D3 in normal T cell development and suggests new therapeutic possibilities in precursor T cell leukemia. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s1535-6108(03)00305-2
更新日期:2003-12-01 00:00:00
abstract::Wnt/β-catenin signaling is essential for stem cell regulation and tumorigenesis, but its molecular mechanisms are not fully understood. Here, we report that FoxM1 is a downstream component of Wnt signaling and is critical for β-catenin transcriptional function in tumor cells. Wnt3a increases the level and nuclear tran...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.08.016
更新日期:2011-10-18 00:00:00
abstract::Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e.g., T cell lymphoma (TCL). Here, Ca2+/calmodulin-dependent protein kinase II γ (CAMKIIγ) was shown to stabilize the c-Myc protein by direct...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.06.001
更新日期:2017-07-10 00:00:00
abstract::The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal epithelium leads to highly penetrant metastasis (100% metastasis; with >80% liver metastases) in KrasG12D-driven serrated cancer. Transcrip...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2019.08.003
更新日期:2019-09-16 00:00:00
abstract::Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understandin...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.11.002
更新日期:2020-11-17 00:00:00