Abstract:
:Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of hereditary (VHL Disease-associated) and sporadic clear cell carcinoma of the kidney. The VHL gene product, pVHL, targets the heterodimeric transcription factor HIF for polyubiquitination, and restoration of pVHL function in VHL(-/-) renal carcinoma cells suppresses their ability to form tumors in nude mice. Here we show that tumor suppression by pVHL can be overridden by a HIF variant that escapes pVHL control. These studies prove that HIF is a critical downstream target of pVHL and establish that activation of HIF target genes can promote tumorigenesis in vivo.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Kondo K,Klco J,Nakamura E,Lechpammer M,Kaelin WG Jrdoi
10.1016/s1535-6108(02)00043-0keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
237-46issue
3eissn
1535-6108issn
1878-3686pii
S1535610802000430journal_volume
1pub_type
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