Species- and cell type-specific requirements for cellular transformation.

Abstract:

:Recent evidence suggests that human cells require more genetic changes for neoplastic transformation than do their murine counterparts. However, a precise enumeration of these differences has never been undertaken. We have determined that perturbation of two signaling pathways-involving p53 and Raf-suffices for the tumorigenic conversion of normal murine fibroblasts, while perturbation of six pathways-involving p53, pRb, PP2A, telomerase, Raf, and Ral-GEFs-is needed for human fibroblasts. Cell type-specific differences also exist in the requirements for tumorigenic transformation: immortalized human fibroblasts require the activation of Raf and Ral-GEFs, human embryonic kidney cells require the activation of PI3K and Ral-GEFs, and human mammary epithelial cells require the activation of Raf, PI3K, and Ral-GEFs.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Rangarajan A,Hong SJ,Gifford A,Weinberg RA

doi

10.1016/j.ccr.2004.07.009

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

171-83

issue

2

eissn

1535-6108

issn

1878-3686

pii

S1535610804002053

journal_volume

6

pub_type

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