ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.

abstract：:In the July issue of Nature Medicine, Massagué and colleagues define a biphasic role for the extracellular matrix protein tenascin C as a metastatic niche component in lung colonization by breast cancer cells. These results provide a rationale for designing therapies targeting metastatic progression by disrupting its ...

journal_title：Cancer cell

authors： Matei I,Ghajar CM,Lyden D

更新日期：2011-08-16 00:00:00

abstract：:TERT promoter mutations reactivate telomerase, allowing for indefinite telomere maintenance and enabling cellular immortalization. These mutations specifically recruit the multimeric ETS factor GABP, which can form two functionally independent transcription factor species: a dimer or a tetramer. We show that genetic d...

journal_title：Cancer cell

authors： Mancini A,Xavier-Magalhães A,Woods WS,Nguyen KT,Amen AM,Hayes JL,Fellmann C,Gapinske M,McKinney AM,Hong C,Jones LE,Walsh KM,Bell RJA,Doudna JA,Costa BM,Song JS,Perez-Pinera P,Costello JF

更新日期：2018-09-10 00:00:00

abstract：:We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3, and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate that miR-29 is repressed by MYC through a corepressor complex with HDAC3 and EZH2. MYC contributes to EZH2 upregulation via repression of the EZH2 t...

journal_title：Cancer cell

authors： Zhang X,Zhao X,Fiskus W,Lin J,Lwin T,Rao R,Zhang Y,Chan JC,Fu K,Marquez VE,Chen-Kiang S,Moscinski LC,Seto E,Dalton WS,Wright KL,Sotomayor E,Bhalla K,Tao J

更新日期：2012-10-16 00:00:00

abstract：:In this issue of Cancer Cell, Sturm et al. report that global DNA methylation patterns in glioblastoma multiforme divide adult and pediatric tumors into subgroups that have characteristic DNA mutations, mRNA profiles, and most importantly, different clinical behaviors. These findings suggest novel opportunities for th...

journal_title：Cancer cell

authors： Raabe EH,Eberhart CG

更新日期：2012-10-16 00:00:00

abstract：:In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved t...

journal_title：Cancer cell

authors： Crispino JD,Le Beau MM

更新日期：2012-11-13 00:00:00

abstract：:Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now underst...

journal_title：Cancer cell

authors： Schmitt AM,Chang HY

更新日期：2016-04-11 00:00:00

abstract：:Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that anti-angiogenic drugs, such as bevacizumab, transiently normalize abnormal tumor vasculature and contribute to improved delivery of subsequent chemotherapy. To investigate this concept, ...

journal_title：Cancer cell

authors： Van der Veldt AA,Lubberink M,Bahce I,Walraven M,de Boer MP,Greuter HN,Hendrikse NH,Eriksson J,Windhorst AD,Postmus PE,Verheul HM,Serné EH,Lammertsma AA,Smit EF

更新日期：2012-01-17 00:00:00

abstract：:Beta-catenin and Tcf4 are the downstream effectors of the Wnt signaling cascade. In colorectal cancer, mutations in Wnt cascade genes such as APC lead to the inappropriate formation of beta-catenin/Tcf4 complexes. Earlier work has predicted that disruption of the beta-catenin/Tcf4 protein-protein interaction could rev...

journal_title：Cancer cell

authors： Clevers H

更新日期：2004-01-01 00:00:00

abstract：:To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples. Our analysis ident...

journal_title：Cancer cell

authors： Gruber TA,Larson Gedman A,Zhang J,Koss CS,Marada S,Ta HQ,Chen SC,Su X,Ogden SK,Dang J,Wu G,Gupta V,Andersson AK,Pounds S,Shi L,Easton J,Barbato MI,Mulder HL,Manne J,Wang J,Rusch M,Ranade S,Ganti R,Parker M,

更新日期：2012-11-13 00:00:00

abstract：:Immune cells' metabolism influences their differentiation and function. Given that a complex interplay of environmental factors within the tumor microenvironment (TME) can have a profound impact on the metabolic activities of immune, stromal, and tumor cell types, there is emerging interest to advance understanding of...

journal_title：Cancer cell

authors： Kaymak I,Williams KS,Cantor JR,Jones RG

更新日期：2021-01-11 00:00:00

abstract：:The budding yeast Saccharomyces cerevisiae is a genetically tractable model system with which to establish the cellular target of a given agent and investigate mechanisms of drug action. ...

journal_title：Cancer cell

authors： Bjornsti MA

更新日期：2002-10-01 00:00:00

abstract：:Chronic exposure to tobacco smoke, which contains over 60 tumor-initiating carcinogens, is the major risk factor for development of lung cancer, accounting for a large portion of cancer-related deaths worldwide. It is well established that tobacco smoke is a tumor initiator, but we asked whether it also acts as a tumo...

journal_title：Cancer cell

authors： Takahashi H,Ogata H,Nishigaki R,Broide DH,Karin M

更新日期：2010-01-19 00:00:00

abstract：:PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation PIK3R1(R348∗) and a nearby mutation PIK3R1(L370fs), in contrast to wild-type and mutations in other regions of PIK3R1, confers an unexpected sensitivity to MEK an...

journal_title：Cancer cell

authors： Cheung LW,Yu S,Zhang D,Li J,Ng PK,Panupinthu N,Mitra S,Ju Z,Yu Q,Liang H,Hawke DH,Lu Y,Broaddus RR,Mills GB

更新日期：2014-10-13 00:00:00

abstract：:Adler et al., in a paper appearing in Nature Genetics, exploited the intersect of genetic information from expression profiles with that from array comparative genomic hybridization in human breast cancers to identify genes that may induce the transcription of the prognostic "wound response" expression signature. The ...

journal_title：Cancer cell

authors： Liu ET,Kuznetsov VA,Miller LD

更新日期：2006-04-01 00:00:00

abstract：:In this issue of Cancer Cell, Park et al. demonstrate that anti-erbB2 antibody primes adaptive immunity for increased tumor clearance and suggest that chemotherapy may in fact interfere with this process. ...

journal_title：Cancer cell

authors： Smyth MJ,Stagg J

更新日期：2010-08-09 00:00:00

abstract：:Tumors are influenced by the mechanical properties of their microenvironment. Using patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver metastases than in primary colorectal tumors. Highly activated metastasis-associated fibroblasts increase tissue stiffness, which enhances a...

journal_title：Cancer cell

authors： Shen Y,Wang X,Lu J,Salfenmoser M,Wirsik NM,Schleussner N,Imle A,Freire Valls A,Radhakrishnan P,Liang J,Wang G,Muley T,Schneider M,Ruiz de Almodovar C,Diz-Muñoz A,Schmidt T

更新日期：2020-06-08 00:00:00

abstract：:Agonistic antibodies specific for members of the tumor necrosis factor receptor protein family hold great promise for immunotherapy of cancer. In this issue of Cancer Cell, White and colleagues provide evidence that the human IgG2 subclass may represent a superior backbone for the use of these antibodies in human ther...

journal_title：Cancer cell

authors： Lux A,Nimmerjahn F

更新日期：2015-01-12 00:00:00

abstract：:Constitutive activation of NF-κB signaling can promote oncogenesis, providing a rationale for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes & Development provide evidence that, in contexts where prosurvival signals derive from other oncogenes, NF-κB activity instead enhances sens...

journal_title：Cancer cell

authors： Klein U,Ghosh S

更新日期：2011-11-15 00:00:00

abstract：:A human pancreatic cancer progression model from intraepithelial neoplasia to ductal adenocarcinoma has been proposed. This process has been modeled in the mouse by activation of mutant Kras in pancreatic progenitor cells. In this issue of Cancer Cell, present a modification of their initial model by introducing a mut...

journal_title：Cancer cell

authors： Siveke JT,Schmid RM

更新日期：2005-05-01 00:00:00

abstract：:Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-kappaB. NF-kappaB proteins themselves and proteins regulated by it have been ...

journal_title：Cancer cell

authors： Aggarwal BB

更新日期：2004-09-01 00:00:00

abstract：:Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations in 50% (22 of 44) of resistant BCCs and show that these mutations maintain Hedgehog signaling in the presence of SMO inhibitors. Alterations include four ligand ...

journal_title：Cancer cell

authors： Atwood SX,Sarin KY,Whitson RJ,Li JR,Kim G,Rezaee M,Ally MS,Kim J,Yao C,Chang AL,Oro AE,Tang JY

更新日期：2015-03-09 00:00:00

abstract：:Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid's group validate c-Raf as a prime target for these cancers. c-Raf ablation caused regression of advanced KRasG12V/Trp53 tumors, without obvious systemic toxicity and without affec...

journal_title：Cancer cell

authors： McCormick F

更新日期：2018-02-12 00:00:00

abstract：:E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukem...

journal_title：Cancer cell

authors： Deb G,Somervaille TCP

更新日期：2016-07-11 00:00:00

abstract：:In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction nee...

journal_title：Cancer cell

authors： Srour N,Mersaoui SY,Richard S

更新日期：2019-07-08 00:00:00

abstract：:The PI3K signaling axis is frequently activated in cancer resulting from inactivation of its negative regulator PTEN or activating mutations of the p110alpha catalytic subunit of PI3K. In this issue of Cancer Cell, Jaiswal et al. report that mutations in the p85alpha regulatory subunit of PI3K can also activate this p...

journal_title：Cancer cell

authors： Berenjeno IM,Vanhaesebroeck B

更新日期：2009-12-08 00:00:00

abstract：:Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in meta...

journal_title：Cancer cell

authors： Bao S,Ouyang G,Bai X,Huang Z,Ma C,Liu M,Shao R,Anderson RM,Rich JN,Wang XF

更新日期：2004-04-01 00:00:00

abstract：:Ampullary carcinomas represent a group of heterogeneous tumors that can be histologically divided into two subtypes with distinct pathogenic and clinical characteristics. Yachida et al. (2016) and Gingras et al. (2016) now report the genomic landscape of ampullary carcinoma, providing insights into molecular drivers w...

journal_title：Cancer cell

authors： Tan J,Tan P,Teh BT

更新日期：2016-02-08 00:00:00

abstract：:From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial protease that has structural similarity to the cytoplasmic proteosome is increased in leukemic cells from approximately half of all patients ...

journal_title：Cancer cell

authors： Cole A,Wang Z,Coyaud E,Voisin V,Gronda M,Jitkova Y,Mattson R,Hurren R,Babovic S,Maclean N,Restall I,Wang X,Jeyaraju DV,Sukhai MA,Prabha S,Bashir S,Ramakrishnan A,Leung E,Qia YH,Zhang N,Combes KR,Ketela T,Lin F

更新日期：2015-06-08 00:00:00

abstract：:To investigate the role of signaling by the small GTPase Ral, we have generated mice deficient for RalGDS, a guanine nucleotide exchange factor that activates Ral. We show that RalGDS is dispensable for mouse development but plays a substantial role in Ras-induced oncogenesis. Lack of RalGDS results in reduced tumor i...

journal_title：Cancer cell

authors： González-García A,Pritchard CA,Paterson HF,Mavria G,Stamp G,Marshall CJ

更新日期：2005-03-01 00:00:00

abstract：:Hepatocellular adenomas (HCAs) are clinically relevant benign liver lesions that commonly occur in women on hormonal contraceptives. In this issue of Cancer Cell, Pilati and colleagues present an integrative multi-"omics"-based analysis of HCA and identify recurrent genetic alterations associated with adenoma-carcinom...

journal_title：Cancer cell

authors： Marquardt JU,Thorgeirsson SS

更新日期：2014-04-14 00:00:00