Abstract:
:Hepatocellular adenomas (HCAs) are clinically relevant benign liver lesions that commonly occur in women on hormonal contraceptives. In this issue of Cancer Cell, Pilati and colleagues present an integrative multi-"omics"-based analysis of HCA and identify recurrent genetic alterations associated with adenoma-carcinoma transition and new drugable targets.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Marquardt JU,Thorgeirsson SSdoi
10.1016/j.ccr.2014.03.032subject
Has Abstractpub_date
2014-04-14 00:00:00pages
409-11issue
4eissn
1535-6108issn
1878-3686pii
S1535-6108(14)00132-9journal_volume
25pub_type
评论,杂志文章相关文献
CANCER CELL文献大全abstract::Studying mechanisms of malignant transformation of human pre-B cells, we found that acute activation of oncogenes induced immediate cell death in the vast majority of cells. Few surviving pre-B cell clones had acquired permissiveness to oncogenic signaling by strong activation of negative feedback regulation of Erk si...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2015.05.008
更新日期:2015-07-13 00:00:00
abstract::Chromosome rearrangements in B lymphocytes can be initiated by AID-associated double strand breaks (DSBs), with others arising by unclear mechanisms. A recent study by Barlow and colleagues in Cell reports on genomic regions, termed early replicating fragile sites, that may explain many AID-independent DSBs and create...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2013.01.017
更新日期:2013-02-11 00:00:00
abstract::ARID1A encodes an SWI/SNF chromatin-remodeling factor and is frequently mutated in various cancers. This study demonstrates that ARID1A-deficient cancer cells are specifically vulnerable to inhibition of the antioxidant glutathione (GSH) and the glutamate-cysteine ligase synthetase catalytic subunit (GCLC), a rate-lim...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.12.009
更新日期:2019-02-11 00:00:00
abstract::MicroRNAs (miRNA) are mostly downregulated in cancer. However, the mechanism underlying this phenomenon and the precise consequence in tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation b...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.10.001
更新日期:2016-11-14 00:00:00
abstract::Even in the presence of an adequate oxygen supply, many tumors metabolize the majority of the glucose they take up through glycolysis. It has been a long-held belief that this glycolytic phenotype is due to cancer-specific defects in mitochondrial oxidative phosphorylation. In this issue of Cancer Cell, Fantin et al. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2006.05.012
更新日期:2006-06-01 00:00:00
abstract::Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX loci as hematopoietic cells mature, thus coinciding with a decrease in HOX gene expression. We show that H3K79 methyltrans...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.10.009
更新日期:2014-12-08 00:00:00
abstract::Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from i...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.08.012
更新日期:2020-09-14 00:00:00
abstract::The cell culture environment (substrate, atmosphere, and medium) can have a significant influence on the characteristics of cells that propagate from clinical samples. In this issue of Cancer Cell, Ince and colleagues report improved conditions for the culture of primary human breast epithelial cells. They demonstrate...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccr.2007.07.012
更新日期:2007-08-01 00:00:00
abstract::The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions. EZH2 represses proliferation checkpoint genes and helps establish bivalent ch...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.04.011
更新日期:2013-05-13 00:00:00
abstract::We identified dynein light chain 1 (DLC1) as a physiologic substrate of p21-activated kinase 1 (Pak1). Pak1-DLC1 interaction plays an essential role in cell survival, which depends on Pak1's phosphorylation of DLC1 on Ser88. Pak1 associates with the complex of DLC1 and BimL, a proapoptotic BH3-only protein, and phosph...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2004.05.022
更新日期:2004-06-01 00:00:00
abstract::The SH2-containing tyrosine phosphatase Shp2 (PTPN11) is required for growth factor and cytokine signaling. Germline Shp2 mutations cause Noonan Syndrome (NS), which is associated with increased risk of juvenile myelomonocytic leukemia (JMML). Somatic Shp2 mutations occur in sporadic JMML and other leukemias. We found...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.01.010
更新日期:2005-02-01 00:00:00
abstract::The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs). Silencing ALKBH5 suppresses the proliferation ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.02.013
更新日期:2017-04-10 00:00:00
abstract::The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2015.10.003
更新日期:2015-12-14 00:00:00
abstract::Overexpression of Bcl-xL, loss of p19 ARF, and loss of p53 all accelerate Myc oncogenesis. All three lesions are implicated in suppressing Myc-induced apoptosis, suggesting that this is a common mechanism by which they synergize with Myc. However, using an acutely switchable model of Myc-induced tumorigenesis, we demo...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.06.017
更新日期:2006-08-01 00:00:00
abstract::One of the biggest challenges in treating acute myeloid leukemia (AML) is relapse of aggressive disease after treatment. In this issue of Cancer Cell, Boyd et al. characterize a molecularly distinct population of chemotherapy-induced transient leukemic regenerating cells (LRCs), which can be exploited to prevent AML r...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2018.08.012
更新日期:2018-09-10 00:00:00
abstract::Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now underst...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2016.03.010
更新日期:2016-04-11 00:00:00
abstract::Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling pathway. However, we show that the related cytokine IL-11 has a stronger correlation with elevated STAT3 activation in human gastrointestinal...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.06.017
更新日期:2013-08-12 00:00:00
abstract::The COVID-19 pandemic is profoundly changing cancer researchers and cancer research. Leaders from different fields and at different career stages share their perspectives. ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.10.007
更新日期:2020-11-09 00:00:00
abstract::Therapies that target estrogen signaling have transformed the treatment of breast cancer. However, the effectiveness of these agents is limited by the development of resistance. Here, an RNAi screen was used to identify modifiers of tamoxifen sensitivity. We demonstrate that CDK10 is an important determinant of resist...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2008.01.001
更新日期:2008-02-01 00:00:00
abstract::Tumors constitute highly suppressive microenvironments in which infiltrating T cells are "exhausted" by inhibitory receptors such as PD-1. Here we identify TIGIT as a coinhibitory receptor that critically limits antitumor and other CD8(+) T cell-dependent chronic immune responses. TIGIT is highly expressed on human an...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.10.018
更新日期:2014-12-08 00:00:00
abstract::Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitant...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.01.027
更新日期:2009-03-03 00:00:00
abstract::We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.12.003
更新日期:2019-01-14 00:00:00
abstract::Our understanding of Ewing's sarcoma development mediated by the EWS/FLI fusion protein has been limited by a lack of knowledge regarding the tumor cell of origin. To circumvent this, we analyzed the function of EWS/FLI in Ewing's sarcoma itself. By combining retroviral-mediated RNA interference with reexpression stud...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.04.004
更新日期:2006-05-01 00:00:00
abstract::Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.05.023
更新日期:2020-07-13 00:00:00
abstract::In this issue of Cancer Cell, Haybaeck et al. unravel the role of lymphotoxin pathway in the development of hepatocellular carcinoma (HCC). Aberrant activation of this cascade in mice livers recapitulates the stages of fibrosis and inflammation that precedes human liver cancer, providing a novel family of potential th...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2009.09.012
更新日期:2009-10-06 00:00:00
abstract::Van den Eynde et al. publish in this issue of Cancer Cell that metastatic colorectal cancer shows marked heterogeneity in T cell infiltration among different lesions and patients. Measurements of T cell infiltration in metastases by immunoscore offer some prognostic information and support immune editing by coevolving...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2018.11.012
更新日期:2018-12-10 00:00:00
abstract::Cancer-associated chromosomal translocations create chimeric oncoproteins that contribute to aberrant growth by dominant or dominant negative mechanisms. Interestingly, genes such as MLL, RARA, and EWS are fused to multiple partners. This molecular promiscuity can provide important functional information, as specific ...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(04)00060-1
更新日期:2004-03-01 00:00:00
abstract::Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are particularly prevalent, occurring in 20% of all human cancers. As these are typicall...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccr.2014.07.018
更新日期:2014-09-08 00:00:00
abstract::The telomere-stabilizing enzyme telomerase is induced in tumors and functionally associated with unlimited replicative potential. To further explore its necessity, transgenic mice expressing SV40 or HPV16 oncogenes, which elicit carcinomas in pancreas and skin, respectively, were rendered telomerase-deficient. Absence...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2004.08.032
更新日期:2004-10-01 00:00:00
abstract::In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus for genomic instability. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.01.011
更新日期:2017-02-13 00:00:00