BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia.

abstract：:It is believed that Mdm2 suppresses p53 in two ways: transcriptional inhibition by direct binding, and degradation via its E3 ligase activity. To study these functions physiologically, we generated mice bearing a single-residue substitution (C462A) abolishing the E3 function without affecting p53 binding. Unexpectedly...

journal_title：Cancer cell

authors： Itahana K,Mao H,Jin A,Itahana Y,Clegg HV,Lindström MS,Bhat KP,Godfrey VL,Evan GI,Zhang Y

更新日期：2007-10-01 00:00:00

abstract：:The cell culture environment (substrate, atmosphere, and medium) can have a significant influence on the characteristics of cells that propagate from clinical samples. In this issue of Cancer Cell, Ince and colleagues report improved conditions for the culture of primary human breast epithelial cells. They demonstrate...

journal_title：Cancer cell

authors： Shay JW,Wright WE

更新日期：2007-08-01 00:00:00

abstract：:Specific phosphoinositide lipids promote cell growth and cancer. In this issue of Cancer Cell, Fayngerts and colleagues demonstrate that the TIPE3 protein enhances PtdIns(4,5)P2 and PtdIns(3,4,5)P3, is overexpressed in certain cancers, and promotes tumorigenesis. TIPE3 can act as a lipid transfer protein and may const...

journal_title：Cancer cell

authors： Moniz LS,Vanhaesebroeck B

更新日期：2014-10-13 00:00:00

abstract：:MYC is an oncogenic driver that regulates transcriptional activation and repression. Surprisingly, mechanisms by which MYC promotes malignant transformation remain unclear. We demonstrate that MYC interacts with the G9a H3K9-methyltransferase complex to control transcriptional repression. Inhibiting G9a hinders MYC ch...

journal_title：Cancer cell

authors： Tu WB,Shiah YJ,Lourenco C,Mullen PJ,Dingar D,Redel C,Tamachi A,Ba-Alawi W,Aman A,Al-Awar R,Cescon DW,Haibe-Kains B,Arrowsmith CH,Raught B,Boutros PC,Penn LZ

更新日期：2018-10-08 00:00:00

abstract：:Chronic exposure to tobacco smoke, which contains over 60 tumor-initiating carcinogens, is the major risk factor for development of lung cancer, accounting for a large portion of cancer-related deaths worldwide. It is well established that tobacco smoke is a tumor initiator, but we asked whether it also acts as a tumo...

journal_title：Cancer cell

authors： Takahashi H,Ogata H,Nishigaki R,Broide DH,Karin M

更新日期：2010-01-19 00:00:00

abstract：:To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-wide screen in yeast identified mitochondrial translation inhibition as the mechanism of tigecycline-mediated lethality. Tigecycline selective...

journal_title：Cancer cell

authors： Skrtić M,Sriskanthadevan S,Jhas B,Gebbia M,Wang X,Wang Z,Hurren R,Jitkova Y,Gronda M,Maclean N,Lai CK,Eberhard Y,Bartoszko J,Spagnuolo P,Rutledge AC,Datti A,Ketela T,Moffat J,Robinson BH,Cameron JH,Wrana J,Eaves

更新日期：2011-11-15 00:00:00

abstract：:Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21(CIP1) checkpoint and cellular senescence at early stages of c...

journal_title：Cancer cell

authors： Takacova S,Slany R,Bartkova J,Stranecky V,Dolezel P,Luzna P,Bartek J,Divoky V

更新日期：2012-04-17 00:00:00

abstract：:We identify a new enzymatic activity underlying metastasis in breast cancer and describe its susceptibility to therapeutic inhibition. We show that human prune (h-prune), a phosphoesterase DHH family appertaining protein, has a hitherto unrecognized cyclic nucleotide phosphodiesterase activity effectively suppressed b...

journal_title：Cancer cell

authors： D'Angelo A,Garzia L,André A,Carotenuto P,Aglio V,Guardiola O,Arrigoni G,Cossu A,Palmieri G,Aravind L,Zollo M

更新日期：2004-02-01 00:00:00

abstract：:Beta-catenin and Tcf4 are the downstream effectors of the Wnt signaling cascade. In colorectal cancer, mutations in Wnt cascade genes such as APC lead to the inappropriate formation of beta-catenin/Tcf4 complexes. Earlier work has predicted that disruption of the beta-catenin/Tcf4 protein-protein interaction could rev...

journal_title：Cancer cell

authors： Clevers H

更新日期：2004-01-01 00:00:00

abstract：:PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation PIK3R1(R348∗) and a nearby mutation PIK3R1(L370fs), in contrast to wild-type and mutations in other regions of PIK3R1, confers an unexpected sensitivity to MEK an...

journal_title：Cancer cell

authors： Cheung LW,Yu S,Zhang D,Li J,Ng PK,Panupinthu N,Mitra S,Ju Z,Yu Q,Liang H,Hawke DH,Lu Y,Broaddus RR,Mills GB

更新日期：2014-10-13 00:00:00

abstract：:It was only 3 years ago that an acquired translocation of EML4 with ALK leading to the expression of an EML4-ALK oncoprotein in non-small cell lung cancer (NSCLC) was reported. Tumor cells expressing EML4-ALK are "addicted" to its continued function. Now, crizotinib, an oral ALK inhibitor, is demonstrated to provide d...

journal_title：Cancer cell

authors： Gerber DE,Minna JD

更新日期：2010-12-14 00:00:00

abstract：:CAR-engineered T cell immunotherapy has proven transformative in selected hematological malignancies. However, solid tumors largely remain impervious to these approaches. In addressing this challenge, Srivastava et al. in this issue demonstrate that oxaliplatin-based lymphodepleting chemotherapy promotes enhanced CAR ...

journal_title：Cancer cell

authors： Davies DM,Maher J

更新日期：2020-12-30 00:00:00

abstract：:The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with e...

journal_title：Cancer cell

authors： Wang Y,Liu Y,Wu C,Zhang H,Zheng X,Zheng Z,Geiger TL,Nuovo GJ,Liu Y,Zheng P

更新日期：2006-09-01 00:00:00

abstract：:Expression of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) is frequently reduced in human colorectal cancer, and this correlates with poor patient prognosis. To clarify the role of p27 in gastrointestinal (GI) cancer, we measured p27 expression, as well as the effect of germline deletion of p27, in 3 differen...

journal_title：Cancer cell

authors： Philipp-Staheli J,Kim KH,Payne SR,Gurley KE,Liggitt D,Longton G,Kemp CJ

更新日期：2002-05-01 00:00:00

abstract：:In this issue of Cancer Cell, Kumar et al. describe how CSF1R blockade induces not only an expected deprivation of tumor-associated macrophages, but also an accumulation of tumor-infiltrating polymorphonuclear mononuclear cells caused by Cxcl-1 released from cancer-associated fibroblasts. ...

journal_title：Cancer cell

authors： Greten TF

更新日期：2017-11-13 00:00:00

abstract：:Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPKCs have pleiotropic context-dependent functions that can translate into ...

journal_title：Cancer cell

authors： Reina-Campos M,Diaz-Meco MT,Moscat J

更新日期：2019-09-16 00:00:00

abstract：:Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from i...

journal_title：Cancer cell

authors： Wu S,Mischel PS

更新日期：2020-09-14 00:00:00

abstract：:The heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and treatment. Identifying and targeting populations of cells driving tumorigenesis is a top priority for the cancer biology field. This is not a trivial task; considerable variance exists in the driving mutations, identifying markers, and...

journal_title：Cancer cell

authors： Lubanska D,Market-Velker BA,deCarvalho AC,Mikkelsen T,Fidalgo da Silva E,Porter LA

更新日期：2014-01-13 00:00:00

abstract：:In this study, we show that the formation of polyploidy following sustained mitotic checkpoint activation appears to be preceded by the ubiquitin-dependent proteolysis of hBubR1. In addition, the level of hBubR1 is significantly reduced not only in polyploid cells created by sustained mitotic spindle damage, but also ...

journal_title：Cancer cell

authors： Shin HJ,Baek KH,Jeon AH,Park MT,Lee SJ,Kang CM,Lee HS,Yoo SH,Chung DH,Sung YC,McKeon F,Lee CW

更新日期：2003-12-01 00:00:00

abstract：:In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain devel...

journal_title：Cancer cell

authors： Chheda MG,Gutmann DH

更新日期：2017-05-08 00:00:00

abstract：:Adoptive T cell immunotherapy is an evolving technology with the potential of providing a means to safely and effectively target tumor cells for destruction. ...

journal_title：Cancer cell

authors： Ho WY,Blattman JN,Dossett ML,Yee C,Greenberg PD

更新日期：2003-05-01 00:00:00

abstract：:STAT3 plays many roles in tumorigenesis. In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine IL-23 in macrophages but inhibits the antitumor cytokine IL-12 in dendritic cells. STAT3 also mediates IL-23's effect of activating t...

journal_title：Cancer cell

authors： Stewart CA,Trinchieri G

更新日期：2009-02-03 00:00:00

abstract：:Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation of NE prostate tumors in the TRAMP mouse model was suppressed in mice lacking the ubiquitin ligase Siah2, which regulates HIF-1alpha availability. Cooperation be...

journal_title：Cancer cell

authors： Qi J,Nakayama K,Cardiff RD,Borowsky AD,Kaul K,Williams R,Krajewski S,Mercola D,Carpenter PM,Bowtell D,Ronai ZA

更新日期：2010-07-13 00:00:00

abstract：:In this issue of Cancer Cell, Sturm et al. report that global DNA methylation patterns in glioblastoma multiforme divide adult and pediatric tumors into subgroups that have characteristic DNA mutations, mRNA profiles, and most importantly, different clinical behaviors. These findings suggest novel opportunities for th...

journal_title：Cancer cell

authors： Raabe EH,Eberhart CG

更新日期：2012-10-16 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs regulate hematopoietic stem cell (HSC) function and contribute to leukemogenesis remains elusive. We found that HOTTIP is aberrantly activated i...

journal_title：Cancer cell

authors： Luo H,Zhu G,Xu J,Lai Q,Yan B,Guo Y,Fung TK,Zeisig BB,Cui Y,Zha J,Cogle C,Wang F,Xu B,Yang FC,Li W,So CWE,Qiu Y,Xu M,Huang S

更新日期：2019-12-09 00:00:00

abstract：:Cancer-associated chromosomal translocations create chimeric oncoproteins that contribute to aberrant growth by dominant or dominant negative mechanisms. Interestingly, genes such as MLL, RARA, and EWS are fused to multiple partners. This molecular promiscuity can provide important functional information, as specific ...

journal_title：Cancer cell

authors： Braun BS,Shannon K

更新日期：2004-03-01 00:00:00

abstract：:TERT promoter mutations reactivate telomerase, allowing for indefinite telomere maintenance and enabling cellular immortalization. These mutations specifically recruit the multimeric ETS factor GABP, which can form two functionally independent transcription factor species: a dimer or a tetramer. We show that genetic d...

journal_title：Cancer cell

authors： Mancini A,Xavier-Magalhães A,Woods WS,Nguyen KT,Amen AM,Hayes JL,Fellmann C,Gapinske M,McKinney AM,Hong C,Jones LE,Walsh KM,Bell RJA,Doudna JA,Costa BM,Song JS,Perez-Pinera P,Costello JF

更新日期：2018-09-10 00:00:00

abstract：:Adler et al., in a paper appearing in Nature Genetics, exploited the intersect of genetic information from expression profiles with that from array comparative genomic hybridization in human breast cancers to identify genes that may induce the transcription of the prognostic "wound response" expression signature. The ...

journal_title：Cancer cell

authors： Liu ET,Kuznetsov VA,Miller LD

更新日期：2006-04-01 00:00:00

abstract：:Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations result in the acquisition of stem cell-like features, overexpression of adhesion molecules causi...

journal_title：Cancer cell

authors： Churchman ML,Qian M,Te Kronnie G,Zhang R,Yang W,Zhang H,Lana T,Tedrick P,Baskin R,Verbist K,Peters JL,Devidas M,Larsen E,Moore IM,Gu Z,Qu C,Yoshihara H,Porter SN,Pruett-Miller SM,Wu G,Raetz E,Martin PL,Bowman

更新日期：2018-05-14 00:00:00

abstract：:Obesity is a leading risk factor for cancer. However, understanding the crosstalk between adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in the field. Here we used a prostate cancer (PCa) mouse model in which the signaling adaptor p62/Sqstm1 is selectively inactivated in adi...

journal_title：Cancer cell

authors： Huang J,Duran A,Reina-Campos M,Valencia T,Castilla EA,Müller TD,Tschöp MH,Moscat J,Diaz-Meco MT

更新日期：2018-04-09 00:00:00