Abstract：
:Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPKCs have pleiotropic context-dependent functions that can translate into tumor-promoter or -suppressive functions. Here, we review early and more recent literature to discuss how the different tumor types, and their microenvironments, might account for the selective signaling of each aPKC isotype. This is of clinical relevance because a better understanding of the roles of these kinases is essential for the design of new anti-cancer treatments.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Reina-Campos M,Diaz-Meco MT,Moscat Jdoi
10.1016/j.ccell.2019.07.010subject
Has Abstractpub_date
2019-09-16 00:00:00pages
218-235issue
3eissn
1535-6108issn
1878-3686pii
S1535-6108(19)30337-Xjournal_volume
36pub_type
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