Defining the Molecular Alterations of Ampullary Carcinoma.

abstract：:The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with e...

journal_title：Cancer cell

authors： Wang Y,Liu Y,Wu C,Zhang H,Zheng X,Zheng Z,Geiger TL,Nuovo GJ,Liu Y,Zheng P

更新日期：2006-09-01 00:00:00

abstract：:Targeted protein degradation is an emerging technology for drug development. An article published in Nature reported a novel mechanism of targeted protein degradation triggered by small-molecule-induced polymerization of the oncogenic transcription factor BCL6. ...

journal_title：Cancer cell

authors： Naito M,Murata S

更新日期：2021-01-11 00:00:00

abstract：:Heterozygous somatic mutations in the spliceosome gene U2AF1 occur in ∼ 11% of patients with myelodysplastic syndromes (MDS), the most common adult myeloid malignancy. It is unclear how these mutations contribute to disease. We examined in vivo hematopoietic consequences of the most common U2AF1 mutation using a doxyc...

journal_title：Cancer cell

authors： Shirai CL,Ley JN,White BS,Kim S,Tibbitts J,Shao J,Ndonwi M,Wadugu B,Duncavage EJ,Okeyo-Owuor T,Liu T,Griffith M,McGrath S,Magrini V,Fulton RS,Fronick C,O'Laughlin M,Graubert TA,Walter MJ

更新日期：2015-05-11 00:00:00

abstract：:The role of Lyn, both a positive and a negative regulator of B and myeloid cells, in chronic lymphocytic leukemia (CLL) has not been well characterized. In this issue of Cancer Cell, Nguyen et al. demonstrated that Lyn in macrophages rather than in CLL cells is critical for the malignancy. ...

journal_title：Cancer cell

authors： Dong S,Byrd JC

更新日期：2016-10-10 00:00:00

abstract：:Although common cancer hallmarks are well established, lineage-restricted oncogenes remain less understood. Here, we report an inherent dependency of melanoma cells on the small GTPase RAB7, identified within a lysosomal gene cluster that distinguishes this malignancy from over 35 tumor types. Analyses in human cells,...

journal_title：Cancer cell

authors： Alonso-Curbelo D,Riveiro-Falkenbach E,Pérez-Guijarro E,Cifdaloz M,Karras P,Osterloh L,Megías D,Cañón E,Calvo TG,Olmeda D,Gómez-López G,Graña O,Sánchez-Arévalo Lobo VJ,Pisano DG,Wang HW,Ortiz-Romero P,Tormo D,Hoek K,Ro

更新日期：2014-07-14 00:00:00

abstract：:ErbB2, a metastasis-promoting oncoprotein, is overexpressed in approximately 25% of invasive/metastatic breast cancers, but in 50%-60% of noninvasive ductal carcinomas in situ (DCIS). It has been puzzling how a subset of ErbB2-overexpressing DCIS develops into invasive breast cancer (IBC). We found that co-overexpress...

journal_title：Cancer cell

authors： Lu J,Guo H,Treekitkarnmongkol W,Li P,Zhang J,Shi B,Ling C,Zhou X,Chen T,Chiao PJ,Feng X,Seewaldt VL,Muller WJ,Sahin A,Hung MC,Yu D

更新日期：2009-09-08 00:00:00

abstract：:Mutational activation of KRas is the first and most frequently detected genetic lesion in pancreatic ductal adenocarcinoma (PDAC). However, the precise role of oncogenic KRas in the pathogenesis of PDAC is not fully understood. Here, we report that the endogenous expression of oncogenic KRas suppresses premature senes...

journal_title：Cancer cell

authors： Lee KE,Bar-Sagi D

更新日期：2010-11-16 00:00:00

abstract：:To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-wide screen in yeast identified mitochondrial translation inhibition as the mechanism of tigecycline-mediated lethality. Tigecycline selective...

journal_title：Cancer cell

authors： Skrtić M,Sriskanthadevan S,Jhas B,Gebbia M,Wang X,Wang Z,Hurren R,Jitkova Y,Gronda M,Maclean N,Lai CK,Eberhard Y,Bartoszko J,Spagnuolo P,Rutledge AC,Datti A,Ketela T,Moffat J,Robinson BH,Cameron JH,Wrana J,Eaves

更新日期：2011-11-15 00:00:00

abstract：:One of the biggest challenges in treating acute myeloid leukemia (AML) is relapse of aggressive disease after treatment. In this issue of Cancer Cell, Boyd et al. characterize a molecularly distinct population of chemotherapy-induced transient leukemic regenerating cells (LRCs), which can be exploited to prevent AML r...

journal_title：Cancer cell

authors： Vu LP,Kharas MG

更新日期：2018-09-10 00:00:00

abstract：:The telomere-stabilizing enzyme telomerase is induced in tumors and functionally associated with unlimited replicative potential. To further explore its necessity, transgenic mice expressing SV40 or HPV16 oncogenes, which elicit carcinomas in pancreas and skin, respectively, were rendered telomerase-deficient. Absence...

journal_title：Cancer cell

authors： Argilla D,Chin K,Singh M,Hodgson JG,Bosenberg M,de Solórzano CO,Lockett S,DePinho RA,Gray J,Hanahan D

更新日期：2004-10-01 00:00:00

abstract：:ARID1A encodes an SWI/SNF chromatin-remodeling factor and is frequently mutated in various cancers. This study demonstrates that ARID1A-deficient cancer cells are specifically vulnerable to inhibition of the antioxidant glutathione (GSH) and the glutamate-cysteine ligase synthetase catalytic subunit (GCLC), a rate-lim...

journal_title：Cancer cell

authors： Ogiwara H,Takahashi K,Sasaki M,Kuroda T,Yoshida H,Watanabe R,Maruyama A,Makinoshima H,Chiwaki F,Sasaki H,Kato T,Okamoto A,Kohno T

更新日期：2019-02-11 00:00:00

abstract：:Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a...

journal_title：Cancer cell

authors： Zheng T,Ménard M,Weiss WA

更新日期：2017-10-09 00:00:00

abstract：:Androgen deprivation therapy (ADT) for advanced prostate cancer inexorably leads to resistance, and clinically useful biomarkers are lacking. The value of genetically engineered mice for coclinical studies is clearly demonstrated in a recent publication that reveals XAF1, XIAP, and SRD5A1 as novel predictive biomarker...

journal_title：Cancer cell

authors： Karantanos T,Thompson TC

更新日期：2013-07-08 00:00:00

abstract：:Immune checkpoint-blockade treatments targeting PD-1/PD-L1 have revolutionized cancer therapy. Hence, understanding the regulation of PD-L1 expression has major clinical relevance. In this issue of Cancer Cell, Lim et al. report that inflammation-induced and NF-κB-driven expression of deubiquitinating enzyme CSN5 lead...

journal_title：Cancer cell

authors： Grinberg-Bleyer Y,Ghosh S

更新日期：2016-12-12 00:00:00

abstract：:Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive genetic data implicating TET2 mutations in myeloid transformation, the consequences of Tet2 loss in hematopoietic development have not b...

journal_title：Cancer cell

authors： Moran-Crusio K,Reavie L,Shih A,Abdel-Wahab O,Ndiaye-Lobry D,Lobry C,Figueroa ME,Vasanthakumar A,Patel J,Zhao X,Perna F,Pandey S,Madzo J,Song C,Dai Q,He C,Ibrahim S,Beran M,Zavadil J,Nimer SD,Melnick A,Godley LA

更新日期：2011-07-12 00:00:00

abstract：:In this issue of Cancer Cell, demonstrate a novel mechanism for the oncogenic activity of MLL chimeric proteins. By providing coiled-coil or other dimerization domains, the cytoplasmic partners of MLL fusion proteins donate a platform for MLL homodimerization, allowing recruitment of accessory factors needed to activa...

journal_title：Cancer cell

authors： Hsu K,Look AT

更新日期：2003-08-01 00:00:00

abstract：:Beta-catenin and Tcf4 are the downstream effectors of the Wnt signaling cascade. In colorectal cancer, mutations in Wnt cascade genes such as APC lead to the inappropriate formation of beta-catenin/Tcf4 complexes. Earlier work has predicted that disruption of the beta-catenin/Tcf4 protein-protein interaction could rev...

journal_title：Cancer cell

authors： Clevers H

更新日期：2004-01-01 00:00:00

abstract：:A subset of B cell acute lymphoblastic leukemia (B-ALL) patients will relapse and succumb to therapy-resistant disease. The bone marrow microenvironment may support B-ALL progression and treatment evasion. Utilizing single-cell approaches, we demonstrate B-ALL bone marrow immune microenvironment remodeling upon diseas...

journal_title：Cancer cell

authors： Witkowski MT,Dolgalev I,Evensen NA,Ma C,Chambers T,Roberts KG,Sreeram S,Dai Y,Tikhonova AN,Lasry A,Qu C,Pei D,Cheng C,Robbins GA,Pierro J,Selvaraj S,Mezzano V,Daves M,Lupo PJ,Scheurer ME,Loomis CA,Mullighan CG,

更新日期：2020-06-08 00:00:00

abstract：:Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in meta...

journal_title：Cancer cell

authors： Bao S,Ouyang G,Bai X,Huang Z,Ma C,Liu M,Shao R,Anderson RM,Rich JN,Wang XF

更新日期：2004-04-01 00:00:00

abstract：:Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissect...

journal_title：Cancer cell

authors： Mok SC,Bonome T,Vathipadiekal V,Bell A,Johnson ME,Wong KK,Park DC,Hao K,Yip DK,Donninger H,Ozbun L,Samimi G,Brady J,Randonovich M,Pise-Masison CA,Barrett JC,Wong WH,Welch WR,Berkowitz RS,Birrer MJ

更新日期：2009-12-08 00:00:00

abstract：:Rapamycin analogs that inhibit mTOR signaling have antitumor activity against certain lymphomas, but treatment of solid tumors has been less encouraging despite inhibition of mTOR function. Two recent papers give insight into the potential use of mTOR inhibitors. O'Reilly et al. provide evidence that poor tumor respon...

journal_title：Cancer cell

authors： Easton JB,Kurmasheva RT,Houghton PJ

更新日期：2006-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations in distinct cell types of the adult pancreas. We show that a subpopulation of Pdx1-expressing cells is susceptible to onco...

journal_title：Cancer cell

authors： Gidekel Friedlander SY,Chu GC,Snyder EL,Girnius N,Dibelius G,Crowley D,Vasile E,DePinho RA,Jacks T

更新日期：2009-11-06 00:00:00

abstract：:Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloi...

journal_title：Cancer cell

authors： Blobel GA,Kalota A,Sanchez PV,Carroll M

更新日期：2011-09-13 00:00:00

abstract：:The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-dama...

journal_title：Cancer cell

authors： Lees-Miller SP

更新日期：2008-05-01 00:00:00

abstract：:Small numbers of proangiogenic bone marrow-derived cells (BMDCs) can play pivotal roles in tumor progression. In this issue of Cancer Cell, two papers, utilizing different tumor angiogenesis models, both find that activated MMP-9 delivered by BMDCs modulates neovessel remodeling, thereby promoting tumor growth. The ch...

journal_title：Cancer cell

authors： Seandel M,Butler J,Lyden D,Rafii S

更新日期：2008-03-01 00:00:00

abstract：:CAR-engineered T cell immunotherapy has proven transformative in selected hematological malignancies. However, solid tumors largely remain impervious to these approaches. In addressing this challenge, Srivastava et al. in this issue demonstrate that oxaliplatin-based lymphodepleting chemotherapy promotes enhanced CAR ...

journal_title：Cancer cell

authors： Davies DM,Maher J

更新日期：2020-12-30 00:00:00

abstract：:Malignant astrocytomas are infiltrative and incurable brain tumors. Despite profound therapeutic implications, the identity of the cell (or cells) of origin has not been rigorously determined. We previously reported mouse models based on conditional inactivation of the human astrocytoma-relevant tumor suppressors p53,...

journal_title：Cancer cell

authors： Alcantara Llaguno S,Chen J,Kwon CH,Jackson EL,Li Y,Burns DK,Alvarez-Buylla A,Parada LF

更新日期：2009-01-06 00:00:00

abstract：:Receptor tyrosine kinase (RTK) recycling is of critical importance for RTK signaling and cancer, yet the process is poorly understood. In this issue, Ye et al. identify GOLM1 as a cargo adaptor that drives hepatocellular carcinoma metastasis by promoting EGFR recycling and provide insights into how this process is reg...

journal_title：Cancer cell

authors： Hung MC,Yang R,Sun Y

更新日期：2016-09-12 00:00:00

abstract：:The increased motility and invasiveness of tumor cells are reminiscent of epithelial-mesenchymal transition (EMT), which occurs during embryonic development, wound healing, and metastasis. In this study, we found that Snail is stabilized by the inflammatory cytokine TNFalpha through the activation of the NF-kappaB pat...

journal_title：Cancer cell

authors： Wu Y,Deng J,Rychahou PG,Qiu S,Evers BM,Zhou BP

更新日期：2009-05-05 00:00:00

abstract：:Recent genome sequencing efforts have identified millions of somatic mutations in cancer. However, the functional impact of most variants is poorly understood. Here we characterize 194 somatic mutations identified in primary lung adenocarcinomas. We present an expression-based variant-impact phenotyping (eVIP) method ...

journal_title：Cancer cell

authors： Berger AH,Brooks AN,Wu X,Shrestha Y,Chouinard C,Piccioni F,Bagul M,Kamburov A,Imielinski M,Hogstrom L,Zhu C,Yang X,Pantel S,Sakai R,Watson J,Kaplan N,Campbell JD,Singh S,Root DE,Narayan R,Natoli T,Lahr DL,Tiro

更新日期：2016-08-08 00:00:00