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Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.

Abstract：

:Malignant astrocytomas are infiltrative and incurable brain tumors. Despite profound therapeutic implications, the identity of the cell (or cells) of origin has not been rigorously determined. We previously reported mouse models based on conditional inactivation of the human astrocytoma-relevant tumor suppressors p53, Nf1, and Pten, wherein through somatic loss of heterozygosity, mutant mice develop tumors with 100% penetrance. In the present study, we show that tumor suppressor inactivation in neural stem/progenitor cells is both necessary and sufficient to induce astrocytoma formation. We demonstrate in vivo that transformed cells and their progeny undergo infiltration and multilineage differentiation during tumorigenesis. Tumor suppressor heterozygous neural stem/progenitor cultures from presymptomatic mice show aberrant growth advantage and altered differentiation, thus identifying a pretumorigenic cell population.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Alcantara Llaguno S,Chen J,Kwon CH,Jackson EL,Li Y,Burns DK,Alvarez-Buylla A,Parada LF

doi

10.1016/j.ccr.2008.12.006

subject

Has Abstract

pub_date

2009-01-06 00:00:00

pages

45-56

issue

1

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(08)00409-1

journal_volume

15

pub_type

杂志文章

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