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Twist1-induced invadopodia formation promotes tumor metastasis.

Abstract：

:The Twist1 transcription factor is known to promote tumor metastasis and induce Epithelial-Mesenchymal Transition (EMT). Here, we report that Twist1 is capable of promoting the formation of invadopodia, specialized membrane protrusions for extracellular matrix degradation. Twist1 induces PDGFRα expression, which in turn activates Src, to promote invadopodia formation. We show that Twist1 and PDGFRα are central mediators of invadopodia formation in response to various EMT-inducing signals. Induction of PDGFRα and invadopodia is essential for Twist1 to promote tumor metastasis. Consistent with PDGFRα being a direct transcriptional target of Twist1, coexpression of Twist1 and PDGFRα predicts poor survival in breast tumor patients. Therefore, invadopodia-mediated matrix degradation is a key function of Twist1 in promoting tumor metastasis.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Eckert MA,Lwin TM,Chang AT,Kim J,Danis E,Ohno-Machado L,Yang J

doi

10.1016/j.ccr.2011.01.036

subject

Has Abstract

pub_date

2011-03-08 00:00:00

pages

372-86

issue

3

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(11)00048-1

journal_volume

19

pub_type

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