Abstract：
:MDM2 has been characterized as a protein that binds to and facilitates degradation of the tumor suppressor p53. Interestingly, more than 40 different splice variants of MDM2 transcripts have been identified both in tumors and normal tissues, and the majority of these variants do not contain sequence encoding the p53 binding site. This review describes the different splice forms, the tissues in which they have been identified, and their association with tumor progression and prognosis. In addition, we discuss the potential functions of these variants and how they interact with full-length MDM2 protein.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Bartel F,Taubert H,Harris LCdoi
10.1016/s1535-6108(02)00091-0keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
9-15issue
1eissn
1535-6108issn
1878-3686pii
S1535610802000910journal_volume
2pub_type
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